El imaginario trágico de la locura : La metáfora agonal y la caracterización de la enfermedad en Orestes de Eurípides

En el teatro griego clásico, el imaginario de la enfermedad trasunta aspectos significativos de las relaciones entre tragedia y medicina hipocrática; en él ocupa un lugar central la metáfora agonal. A partir de este presupuesto, el presente trabajo se centrará en el análisis de la metáfora agonal en Orestes de Eurípides (408 a.C.). Imágenes provenientes del campo atlético y militar, asociadas a la marcada presencia del término agón, reflejan en esta tragedia euripidea tardía la violencia de la locura. El objetivo del presente trabajo será demostrar de qué modo este imaginario singular muestra en el drama aspectos conflictivos de la indisociable relación entre el matricida y su nósos, y revela la patología de la locura como irrupción de una lucha entre fuerzas que pugnan en el interior del mismo Orestes

El imaginario trágico de la locura : La metáfora agonal y la caracterización de la enfermedad en Orestes de Eurípides

En el teatro griego clásico, el imaginario de la enfermedad trasunta aspectos significativos de las relaciones entre tragedia y medicina hipocrática; en él ocupa un lugar central la metáfora agonal. A partir de este presupuesto, el presente trabajo se centrará en el análisis de la metáfora agonal en Orestes de Eurípides (408 a.C.). Imágenes provenientes del campo atlético y militar, asociadas a la marcada presencia del término agón, reflejan en esta tragedia euripidea tardía la violencia de la locura. El objetivo del presente trabajo será demostrar de qué modo este imaginario singular muestra en el drama aspectos conflictivos de la indisociable relación entre el matricida y su nósos, y revela la patología de la locura como irrupción de una lucha entre fuerzas que pugnan en el interior del mismo Orestes

El imaginario trágico de la locura : La metáfora agonal y la caracterización de la enfermedad en Orestes de Eurípides

En el teatro griego clásico, el imaginario de la enfermedad trasunta aspectos significativos de las relaciones entre tragedia y medicina hipocrática; en él ocupa un lugar central la metáfora agonal. A partir de este presupuesto, el presente trabajo se centrará en el análisis de la metáfora agonal en Orestes de Eurípides (408 a.C.). Imágenes provenientes del campo atlético y militar, asociadas a la marcada presencia del término agón, reflejan en esta tragedia euripidea tardía la violencia de la locura. El objetivo del presente trabajo será demostrar de qué modo este imaginario singular muestra en el drama aspectos conflictivos de la indisociable relación entre el matricida y su nósos, y revela la patología de la locura como irrupción de una lucha entre fuerzas que pugnan en el interior del mismo Orestes

Agonistic behavior and environmental enrichment of cats communally housed in a shelter

Objective-To evaluate the presence of a dominance rank in a group of cats and the relation between agonistic behavior and the use of resources, including environmental enrichment, in these cats. Design-Observational analytic study. Animals-27 neutered cats in a shelter in Sao Paulo, Brazil. Procedures-The cats were video recorded for 4 consecutive days to obtain baseline data. Subsequently, a puzzle feeder was added as an enrichment device every other day over 8 days, for a total of 4 days with enrichment. Cats were also video recorded on these days. All pretreatment and posttreatment agonistic behaviors and interactions with the puzzle feeder were recorded by reviewing the videotapes. Results-143 agonistic encounters were recorded, of which 44 were related to resources and 99 were not. There were insufficient agonistic interactions to determine a dominance rank. Presence or absence of the puzzle feeder did not affect the rate of aggression. There was no significant effect of weight, sex, or coat color on the rate of aggression, and aggressive behavior did not correlate with time spent with the puzzle feeder. Twenty-three of the 27 cats interacted with the puzzle feeder. Conclusions and Clinical Relevance-In a stable group of communally housed cats, environmental enrichment did not cause increased aggression as a result of competition for the source of enrichment. Because environmental enrichment increases the opportunity to perform exploratory behaviors, it may improve the welfare of groups of cats maintained long-term in shelters, sanctuaries, or multicat households. (J Am Vet Med Assoc 2011239:796-802)

Cellular prion protein modulates defensive attention and innate fear-induced behaviour evoked in transgenic mice submitted to an agonistic encounter with the tropical coral snake Oxyrhopus guibei

The cellular prion protein (PrPC) is a neuronal anchored glycoprotein that has been associated with distinct functions in the CNS, such as cellular adhesion and differentiation, synaptic plasticity and cognition. Here we investigated the putative involvement of the PrPC in the innate fear-induced behavioural reactions in wild-type (WT), PrPC knockout (Prnp(0/0)) and the PrPC overexpressing Tg-20 mice evoked in a prey versus predator paradigm. The behavioural performance of these mouse strains in olfactory discrimination tasks was also investigated. When confronted with coral snakes, mice from both Prnp(0/0) and Tg-20 strains presented a significant decrease in frequency and duration of defensive attention and risk assessment, compared to WT mice. Tg-20 mice presented decreased frequency of escape responses, increased exploratory behaviour, and enhancement of interaction with the snake, suggesting a robust fearlessness caused by PrPC overexpression. Interestingly, there was also a discrete decrease in the attentional defensive response (decreased frequency of defensive alertness) in Prnp(0/0) mice in the presence of coral snakes. Moreover, Tg-20 mice presented an increased exploration of novel environment and odors. The present findings indicate that the PrPC overexpression causes hyperactivity, fearlessness, and increased preference for visual, tactile and olfactory stimuli-associated novelty, and that the PrPC deficiency might lead to attention deficits. These results suggest that PrPC exerts an important role in the modulation of innate fear and novelty-induced exploration. (C) 2008 Published by Elsevier B.V.

Crises as a disease of the body politick: a metaphor in the history of nineteenth century economics

This paper examines the use of the medical metaphor in the early theories of crises. It first considers the borrowing of medical terminology and generic references to disease which, notwithstanding their relatively trivial character, illustrate how crises were originally conceived as disturbances (often of a political nature) to a naturally healthy system. Then it shows how a more specific metaphor, the fever of speculation, shifted the emphasis by treating prosperity as the diseased phase, to which crises are a remedy. The metaphor of the epidemic spreading of the disease introduced the theme of the cumulative character of both upswing and downswing, while the similitude with intermittent fevers accounted for the recurring nature of crises. Finally, the paper examines how the medical reflections on the causality of diseases contributed to the epistemology of crises theory, and reflects on the metaphisical shift accompanying the transition from the theories of crises to the theories of cycles.

Development of an Fn14 agonistic antibody as an anti-tumor agent.

TWEAK, a TNF family ligand with pleiotropic cellular functions, was originally described as capable of inducing tumor cell death in vitro. TWEAK functions by binding its receptor, Fn14, which is up-regulated on many human solid tumors. Herein, we show that intratumoral administration of TWEAK, delivered either by an adenoviral vector or in an immunoglobulin Fc-fusion form, results in significant inhibition of tumor growth in a breast xenograft model. To exploit the TWEAK-Fn14 pathway as a therapeutic target in oncology, we developed an anti-Fn14 agonistic antibody, BIIB036. Studies described herein show that BIIB036 binds specifically to Fn14 but not other members of the TNF receptor family, induces Fn14 signaling, and promotes tumor cell apoptosis in vitro. In vivo, BIIB036 effectively inhibits growth of tumors in multiple xenograft models, including colon (WiDr), breast (MDA-MB-231), and gastric (NCI-N87) tumors, regardless of tumor cell growth inhibition response observed to BIIB036 in vitro. The anti-tumor activity in these cell lines is not TNF-dependent. Increasing the antigen-binding valency of BIB036 significantly enhances its anti-tumor effect, suggesting the contribution of higher order cross-linking of the Fn14 receptor. Full Fc effector function is required for maximal activity of BIIB036 in vivo, likely due to the cross-linking effect and/or ADCC mediated tumor killing activity. Taken together, the anti-tumor properties of BIIB036 validate Fn14 as a promising target in oncology and demonstrate its potential therapeutic utility in multiple solid tumor indications.