De samsöa

Invocatio: I.N.J.C.

Immediate loading of implants with 3-unit fixed partial dentures: a 12-month clinical study

PURPOSE: The aim of the present clinical trial was to evaluate the 12-month success rate of titanium dental implants placed in the posterior mandible and immediately loaded with 3-unit fixed partial dentures. MATERIALS AND METHODS: Patients with missing mandibular premolars and molars were enrolled in this study. To be included in the study, the implants had to show good primary stability. Implant stability was measured with resonance frequency analysis using the Osstell device (Integration Diagnostics). Implants were included in the study when the stability quotient (ISQ) exceeded 62. Clinical measurements, such as width of keratinized tissue, ISQ, and radiographic assessment of peri-implant bone crest levels, were performed at baseline and at the 12-month follow-up. The comparison between the baseline and the 12-month visits was performed with the Student t test for paired data (statistically significant at a level of alpha = 0.05). RESULTS: Forty implants with a sandblasted, large grit, acid-etched (SLA) surface (Straumann) were placed in 20 patients. At 12 months, only 1 implant had been lost because of an acute infection. The remaining 39 implants were successful, resulting in a 1-year success rate of 97.5%. Neither peri-implant bone levels, measured radiographically, nor implant stability changed significantly from baseline to the 12-month follow-up (P > .05). DISCUSSION: The immediate functional loading of implants placed in this case series study resulted in a satisfactory success rate. CONCLUSION: The findings from this clinical study showed that the placement of SLA transmucosal implants in the mandibular area and their immediate loading with 3-unit fixed partial dentures may be a safe and successful procedure.

Valved stents for transapical pulmonary valve replacement

OBJECTIVES: Pulmonary valve insufficiency remains a leading cause for reoperations in congenital cardiac surgery. The current percutaneous approach is limited by the size of the access vessel and variable right ventricular outflow tract morphology. This study assesses the feasibility of transapical pulmonary valve replacement based on a new valved stent construction concept. METHODS: A new valved stent design was implanted off-pump under continuous intracardiac echocardiographic and fluoroscopic guidance into the native right ventricular outflow tract in 8 pigs (48.5 +/- 6.0 kg) through the right ventricular apex, and device function was studied by using invasive and noninvasive measures. RESULTS: Procedural success was 100% at the first attempt. Procedural time was 75 +/- 15 minutes. All devices were delivered at the target site with good acute valve function. No valved stents dislodged. No animal had significant regurgitation or paravalvular leaking on intracardiac echocardiographic analysis. All animals had a competent tricuspid valve and no signs of right ventricular dysfunction. The planimetric valve orifice was 2.85 +/- 0.32 cm(2). No damage to the pulmonary artery or structural defect of the valved stents was found at necropsy. CONCLUSIONS: This study confirms the feasibility of direct access valve replacement through the transapical procedure for replacement of the pulmonary valve, as well as validity of the new valved stent design concept. The transapical procedure is targeting a broader patient pool, including the very young and the adult patient. The device design might not be restricted to failing conduits only and could allow for implantation in a larger patient population, including those with native right ventricular outflow tract configurations.

Autosuficiencia y seguridad alimentaria sustentada en la promotoria rural en 8 comunidades del municipio de Río Blanco, Matagalpa: Pasantía Junio-Diciembre 2014, Fundación Ayuda en Acción, Proyecto “Extremadura y Gestión de Auspiciamiento”

El proceso de pasantía es una cadena de aprendizaje y una formas de culminació n de estudios la cual se realizaron con el fin de optar al título profesional de Licenciatura en Desarrollo Rural, las pasantías han sido realizadas en la Fundación Ayuda en Acción (AeA), en el Área de Desarrollo Territorial (ADT) del Municipio de Rio Blanco -Matagalpa, en el período compre ndido de Junio a Diciembre del 2014. La Fundación AeA es una organización No Gubernamental de Desarrollo (ONGD) independiente, aconfesional y apartidista, fundada en España en 1981. Los proyectos que implementa son intersectoriales, articulando acciones en educación, salud, prevención de riesgos, gobernabilidad, seguridad y soberanía alimentaria entre otros, con la finalidad de impulsar cambios estructurales que contribuyan a la erradicación de la pobreza. El área de trabajo asignada al pasante estuvo enfoc ada en proyectos productivos, dirigidos a mejorar los ingresos de las familias, dietas alimenticias, nutrición, así como la creación de conocimientos en diferentes temáticas a través capacitaciones. Entre las funciones asignadas al pasante se menciona: proceso se apoyó al desarrollo y ejecución organizativa del proyecto “Familias Campesinas Promoviendo la Soberanía y Seguridad Alimentaria con participación de actores locales en 15 Comunidades de Matigüas y Río Blanco” (Extremadura) sust entada en la promoto ria rural, e n esta área el pasante trabajó en 8 Comunida des en la identificación y selección de las familias participantes del proyecto Extremadura apoyando a 188 familias capacitadas y a implementar la producción agroecológica . Otras actividades orientadas al pasante fue facilitar eventos de capacitación, reuniones, talleres e intercambios de experiencia, elaboración de informes, levantar información secundaria, coordinar y planificar con el equipo técnico. Otra área de trabajo donde el susténtate se desempeñó fue el desarrollo de las actividades del programa “Gestión de Auspiciamiento (GdA) y Vinculo Solidario (VS) donde se recolectar on 914 mensajes de la niñez auspiciada en 18 Comunidades y 3 barrios en el ADT de Rio Blan co, el auspiciamiento es la relación entre una niño/a nicaragüense y una ciudadana Español o Ingles, basada en la dignidad y la acción solidaria. Está relación permite que a través del intercambio de comunicaciones fortalecer las relaciones humanas, motiva r la solidaridad y emprender proyectos de desarrollo Comunitarios . El pasante trabajo en actividades extra pal orientadas donde facilito 4 talleres los cuales iban dirigidos a hombre y mujeres para extraer información y hacer un analices para la actualización del diagnóstico del municipio para que la Fundación pueda formular nuevos proyectos partiendo del Análisis una Realidad analizar . También como actividades extra plan al pasante le orientaron trabajar en el desarrollo de actividades del proyecto SSAN . En cuanto al desarrollo de la pasantía es necesario que desde un inicio se establezcan coordinaciones y planes entre la universidad y la fundación donde el pasante desempeñara sus funciones .

Synthesis And Antiproliferative Activity Of 8-hydroxyquinoline Derivatives Containing A 1,2,3-triazole Moiety.

Twelve novel 8-hydroxyquinoline derivatives were synthesized with good yields by performing copper-catalyzed Huisgen 1,3-dipolar cycloaddition (click reaction) between an 8-O-alkylated-quinoline containing a terminal alkyne and various aromatic or protected sugar azides. These compounds were evaluated in vitro for their antiproliferative activity on various cancer cell types. Protected sugar derivative 16 was the most active compound in the series, exhibiting potent antiproliferative activity and high selectivity toward ovarian cancer cells (OVCAR-03, GI50 < 0.25 μg mL(-1)); this derivative was more active than the reference drug doxorubicin (OVCAR-03, GI50 = 0.43 μg mL(-1)). In structure-activity relationship (SAR) studies, the physico-chemical parameters of the compounds were evaluated and docking calculations were performed for the α-glucosidase active site to predict the possible mechanism of action of this series of compounds.

Characterization Of A Protein-protein Interaction Network Of The Cbl-interacting Protein Kinase 8 From Sugarcane.

Plants are sessile organisms and have evolved to tolerate a constantly changing environment. After the onset of different stress conditions, calcineurin B-like (CBL) proteins can sense calcium signals and activate CBL-interacting protein kinase (CIPK) proteins, which can phosphorylate downstream proteins to reestablish plant homeostasis. Previous studies in the bioenergy crop sugarcane showed that the ScCIPK8 gene is induced by drought stress and is also related to sucrose content. Here, we have characterized the protein-protein interactions of ScCIPK8 with six CBL proteins (ScCBL1, ScCBL2, ScCBL3, ScCBL6, ScCBL9, and ScCBL10). Yeast two-hybrid assays showed that ScCIPK8 interacts with ScCBL1, ScCBL3, and ScCBL6. Bimolecular fluorescence complementation assays confirmed in planta the interactions that were observed in yeast cells. These findings give insights on the regulatory networks related to sugar accumulation and drought stress responses in sugarcane.

Antioxidative responses of cell suspension cultures of two Coffea arabica varieties to low aluminum levels at pH 5.8

The effects of aluminum (Al) on the activities of antioxidant enzymes and ferritin expression were studied in cell suspension cultures of two varieties of Coffea arabica, Mundo Novo and Icatu, in medium with pH at 5.8. The cells were incubated with 300 µM Al3+, and the Al speciation as Al3+ was 1.45% of the mole fraction. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) were increased in Mundo Novo, whereas glutathione reductase (GR) and guaiacol peroxidase (GPOX) activities remained unchanged. SOD, GR, and GST activities were increased in Icatu, while CAT activity was not changed, and GPOX activity decreased. The expression of two ferritin genes (CaFer1 and CaFer2) were analyzed by Real-Time PCR. Al caused a downregulation of CaFER1 expression and no changes of CaFER2 expression in both varieties. The Western blot showed no alteration in ferritin protein levels in Mundo Novo and a decrease in Icatu. The differential enzymes responses indicate that the response to Al is variety-dependent.

Long-term follow-up of an 8-year-old boy with insulinoma as the first manifestation of a familial form of multiple endocrine neoplasia type 1

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary cancer syndrome characterized mostly by parathyroid, enteropancreatic, and anterior pituitary tumors. We present a case of an 8-year-old boy referred because of hypoglycemic attacks. His diagnosis was pancreatic insulinoma. Paternal grandmother died due to repeated gastroduodenal ulcerations and a paternal aunt presented similar manifestations. At a first evaluation, the father presented only gastric ulceration but subsequently developed hyperparathyroidism and lung carcinoid tumor. During almost 15 years of follow-up, three brothers and the index case presented hyperparathyroidism and hyperprolactinemia. Molecular study showed a G to A substitution in intron 4, at nine nucleotides upstream of the splicing acceptor site, causing a splicing mutation. All affected members of the family have the same mutation. Paternal grandmother and aunt were not studied and the mother does not carry any mutation. MEN1 is a rare condition that requires permanent medical assistance. Early clinical and genetic identification of affected individuals is essential for their own surveillance and also for genetic counseling.