Avaliação da dosagem direta do colesterol-LDL em amostras de sangue de 10.664 pacientes em comparação com o uso da fórmula de Friedewald

OBJETIVO: Avaliar a dosagem direta do colesterol LDL (LDL-C) por um método homogêneo, em comparação com a estimativa pela fórmula de Friedewald, em uma grande população heterogênea. MÉTODOS: As dosagens do colesterol total (ColT) e dos triglicerídeos (Trig) foram realizadas por métodos enzimáticos tradicionais. As dosagens do HDL-C e do LDL-C foram realizadas por métodos diretos, sem precipitação, e a estimativa da fração LDL-C calculada pela fórmula de Friedewald. RESULTADOS: Por análise de regressão linear, os dois métodos apresentaram coeficientes de correlação extremamente significativos (p<0,001). Entretanto, a fórmula de Friedewald apresentou um bias positivo em relação ao método direto, mais pronunciado com níveis de ColT > 201 mg/dL. Este bias positivo também ocorreu com relação a níveis de Trig < 150 mg/dL. Com níveis de Trig entre 151-200 mg/dL e entre 201-300 mg/dL, não foi observado bias entre os dois métodos. Por outro lado, com níveis de Trig entre 301-400 mg/dL, este bias da fórmula de Friedewald tornou-se negativo. CONCLUSÃO: Foi possível demonstrar que a fórmula de Friedewald não apresenta um desempenho homogêneo para a estimativa do LDL-C em amostras com diferentes níveis de Trig, em comparação com o método direto, podendo causar dúvidas na classificação quanto ao risco de desenvolver doença arterial coronariana.

Sobre una inscripció ibèrica suspecta: MNAT 664

L'objectiu d'aquest treball és reivindicar l'autenticitat d'una inscripció ibèrica conservada al MNAT des de temps antic i condemnada sense causa justificada.

Low-Cost Rural Surface Alternatives: Demonstration Project, TR-664, 2015

The goals of this project were to implement several stabilization methods for preventing or mitigating freeze-thaw damage to granular surfaced roads and identify the most effective and economical methods for the soil and climate conditions of Iowa. Several methods and technologies identified as potentially suitable for Iowa were selected from an extensive analysis of existing literature provided with Iowa Highway Research Board (IHRB) Project TR-632. Using the selected methods, demonstration sections were constructed in Hamilton County on a heavily traveled two-mile section of granular surfaced road that required frequent maintenance during previous thawing periods. Construction procedures and costs of the demonstration sections were documented, and subsequent maintenance requirements were tabulated through two seasonal freeze-thaw periods. Extensive laboratory and field tests were performed prior to construction, as well as before and after the two seasonal freeze-thaw periods, to monitor the performance of the demonstration sections. A weather station was installed at the project site and temperature sensors were embedded in the subgrade to monitor ground temperatures up to a depth of 5 ft and determine the duration and depths of ground freezing and thawing. An economic analysis was performed using the documented construction and maintenance costs, and the estimated cumulative costs per square yard were projected over a 20-year timeframe to determine break-even periods relative to the cost of continuing current maintenance practices. Overall, the sections with biaxial geogrid or macadam base courses had the best observed freeze-thaw performance in this study. These two stabilization methods have larger initial costs and longer break-even periods than aggregate columns, but counties should also weigh the benefits of improved ride quality and savings that these solutions can provide as excellent foundations for future paving or surface upgrades.

Resolución 664(XXXIV): Admisión de Guadalupe como como miembro asociado de la Comisión Económica para América Latina y el Caribe

Versión en inglés disponible en Biblioteca

Resolution 664(XXXIV) Admission of Guadeloupe as an associate member of the Economic Commission for Latin America and the Caribbean

Spanish version available

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 664 - Weiterleitung eines Briefes und Angaben zur Quittung von 3.172 Thaler und 12 Groschen

u.a.: Geschäfte mit dem Bankhaus Muhl;

Na 1 Nachlass Max Horkheimer, 664 - "Research-Project on Anti-Semitism" (p. IX 92.8-IX 100)

International Institute of Social Research: Research-Project on Anti-Semitism" (1939-42) (veröffentlicht in Studies in Philosophy and Social Science Bd. IX, 1941, S. 124-143): 8. American Jewish Committee, Library: 1 Brief mit Unterschrift an Institute of Social Research, New York, 01.05.1941, 1 Brief mit Unterschrift von Institute of Social Research, New York, 3.5.1941, 2 Blatt; "Re: Anti-Semitism Project of the Institute of Social Research" (1941), Typoskript, 2 Blatt; "Remarks to the new form of the Project on Anti-Semitism" (27.10.1942), Typoskript, 10 Blatt; "Memorandum on a Research-Project on Anti-Semitism" (30.10.1942), a) Typoskript, 14 Blatt, b) Typoskript mit handschriftlichen Bemerkungen, 14 Blatt; Robert S. Lynd: Kommentar zu einer Beschreibung des Antisemitismus-Projekts vom 06.12.1942, Typoskript, englisch, mit handschriftlichen Korrekturen, 3 Blatt; "Outline of a Research Project on Anti-Semitism, prepared for the American Jewish Committee" (15.12.1942), a) Typoskript, 17 Blatt, b) Typoskript, 18 Blatt, c) Teilstück, Typoskript mit handschriftlichen Bemerkungen, 10 Blatt; "Memorandum on the Project on Antisemitism" (30.12.1942), a) Typoskript, 17 Blatt, b) Typoskript mit handschriftlichen Ergänzungen, 16 Blatt; "Some Methodological Errors in the Study of Antisemitism" (Januar 1943), Typoskript, 6 Blatt; "Intermediate Joint Meeting of the Institute of Social Research and the American Jewish Committee", Sitzungsprotokolle 01.03. - 27.07. 1943, Typoskripte mit handschriftlichen Korrekturen, 100 Blatt;

Stable isotope ratios of benthic foraminifera in mid-Pleitsocene sediments of ODP Site 108-664 in the equatorial Atlantic

Five delta13C records from the deep ocean, extending back to 1.3 Ma, were examined in order to constrain changes in mean ocean carbon isotope composition and thermohaline circulation over the 41- to 100-ka climate transition. These data show that significant perturbations in mean ocean carbon chemistry were associated with the mid-Pleistocene climate transition. Notable features of the last 1.3 Myr are (1) a pronounced ~0.3? decrease in mean ocean delta13C between 0.9 and 1.0 Myr, followed by a return to pre-1.0 Ma values by 400 ka B.P., which we propose was due to the onetime addition of isotopically depleted terrestrial carbon to the ocean, possibly associated with an increase in global aridity (and decrease in the size of the biosphere) across the 41- to 100-ka transition; (2) no change in the Atlantic-Pacific (A-P) delta13C gradient over the last 1.3 Myr, suggesting no change in mean ocean nutrient content accompanied the addition of light carbon; and (3) stronger vertical nutrient fractionation in the North Atlantic in the middle Pleistocene between sites 607 and 552, suggesting weaker North Atlantic Deep Water formation at this time relative to the early and late Pleistocene. We also find evidence for a more pronounced deep recirculation gyre in the western North Atlantic basin in the early Brunhes, as evidenced by "aging" of deep northern basin water (site 607) relative to deep water in the equatorial Atlantic (site 664).