986 resultados para 409


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The detection and replication of schizophrenia risk loci can require substantial sample sizes, which has prompted various collaborative efforts for combining multiple samples. However, pooled samples may comprise sub-samples with substantial population genetic differences, including allele frequency differences. We investigated the impact of population differences via linkage reanalysis of Molecular Genetics of Schizophrenia 1 (MGS1) affected sibling-pair data, comprising two samples of distinct ancestral origin: European (EA: 263 pedigrees) and African-American (AA: 146 pedigrees). To exploit the linkage information contained within these distinct continental samples, we performed separate analyses of the individual samples, allowing for within-sample locus heterogeneity, and the pooled sample, allowing for both within-sample and between-sample heterogeneity. Significance levels, corrected for the multiple tests, were determined empirically. For all suggestive peaks, stronger linkage evidence was obtained in either the EA or AA sample than the combined sample, regardless of how heterogeneity was modeled for the latter. Notably, we report genomewide significant linkage of schizophrenia to 8p23.3 and evidence for a second, independent susceptibility locus, reaching suggestive linkage, 29 cM away on 8p21.3. We also detected suggestive linkage on chromosomes 5p13.3 and 7q36.2. Many regions showed pronounced differences in the extent of linkage between the EA and AA samples. This reanalysis highlights the potential impact of population differences upon linkage evidence in pooled data and demonstrates a useful approach for the analysis of samples drawn from distinct continental groups.

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Terminou à meia noite o prazo para os pedidos de destaque para as emendas ao projeto da Constituição. Foram feitos ao todo 2300 pedidos. Todas as providências já foram tomadas para que os 559 constituintes comecem a votar amanhã a nova Constituição do país. Ulysses Guimarães acerta os detalhes das próximas sessões. No primeiro dia de votação será votado o preâmbulo e o título 1º, que trata da introdução dos princípios gerais da Constituição. As votações se darão de segunda a sexta feira, na parte da tarde. Não haverá votação nos fins de semana. Será usado o painel eletrônico para as votações. Dois oradores falarão a favor e dois contra a proposta em votação. Acordo entre as lideranças, quorum e esforço em eliminar emendas repetitivas ajudarão na celeridade dos trabalhos.

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Contient : 1° « Le Mariage Nostre Dame » ; 2° Homélies sur « la feste de Nouel... l'offerende des.III. rois... la Purificacion Nostre Dame sainte Marie,... la Presentacion » ; 3° « La Passion Nostre Seigneur Jhesu Crist » ; 4° Homélies sur « la conversion saint Poul » ; 5° La Somme le roi [de Frère LAURENT] ; 6° « La Vie de la Magdeleine » ; 7° Lamentations Notre Dame

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Pour toute demande de reproduction de contenu se trouvant dans cette publication, communiquer avec l’Association des diplômés de l’UdeM.

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An information processor for rendering input data compatible with standard video recording and/or display equipment, comprizing means for digitizing the input data over periods which are synchronous with the fields of a standard video signal, a store adapted to store the digitized data and release stored digitized data in correspondence wiht the line scan of a standard video monitor, the store having two halves which correspond to the interlaced fields of a standard video signal and being so arranged that one half is filed while the other is emptied, and means for converting the released stored digitized data into video luminance signals. The input signals may be in digital or analogue form. A second stage which reconstitutes the recorded data is also described.

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Male Holtzman rats weighting 200-250 g were anesthetized with zoletil 50 mg/Kg (tiletamine chloridrate 125,0 mg and zolazepan chloridrate 125,0 mg) into quadriceps muscle and submitted an electrolytic lesion of the lateral hypothalamus (LH) and a stainless steel cannula was implanted into their median preoptic nucleus (MnPO). We investigated the effects of the injection into the (MnPO) of FK 409 (20 mug/0.5 mul), a nitric oxide (NO) donor, and N-W-nitro-L-arginine methyl ester (L-NAME) 40 mug/0.5 mul, a nitric oxide synthase inhibitor (NOSI), on the water and sodium appetite and the natriuretic, diuretic and cardiovascular effects induced by injection of L-NAME and FK 409 injected into MnPO in rats with LH lesions. Controls were injected with a similar volume of 0.15 M NaCl. L-NAME injected into MnPO produced an increase in water and sodium intake and in sodium and urine excretion and increase de mean arterial pressure (MAP). FK 409 injected into MnPO did not produce any change in the hydro electrolytic and cardiovascular parameters in LH-sham and lesioned rats. FK 409 injected before L-NAME attenuated its effects. These data show that electrolytic lesion of the LH reduces fluid and sodium intake as well as sodium and urine excretion, and the pressor effect induced by L-NAME. LH involvement with NO of the MnPO excitatory and inhibitory mechanisms related to water and sodium intake, sodium excretion and cardiovascular control is suggested. (C) 2004 Elsevier B.V. All rights reserved.

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76 Briefe zwischen Henryk Grossmann und Max Horkheimer, 1934 - 1949; 1 Brief von F. Pollock an K. H. Hennings, 13.07.1967; 2 Briefe zwischen Max Horkheimer und George Rainer, September 1950; 1 Brief von M. Kisling an Henryk Grossmann, 13.01.1950; 4 Briefe von Friedrich Pollock an Frederick Wild 1948 - 1949; 1 Brief von Henryk Grossmann an die Social Studies Association (New York), 05.05.1946; 1 Brief von Friedrich Pollock an die Social Studies Association (New York), 18.01.1949; 1 Brief von Max Horkheimer an den American Consul General (Habana), 26.04.1938; 1 Brief von Max Horkheimer an die New York Section of the National Council of Jewish Women (New York), 18.04.1938;