(Table 1) Magnetic susceptibility, lithologic composition and stable isotope record for ODP Hole 132-810C

Site 810 was drilled atop Shatsky Rise during Ocean Drilling Program (ODP) Leg 132. The principal objective at Site 810 was to drill interbedded cherts and chalks of Mesozoic age using the diamond coring system (DCS). The objective was not achieved because of difficulties in setting up the reentry cone on the seafloor; however, a shortened section of Cretaceous-Cenozoic nannofossil ooze was recovered with the advanced piston corer (APC). Although the section is interrupted by hiatuses, the upper 50 m carry detailed information relating to biogenic productivity, water chemistry, and eolian input during the Pliocene and Pleistocene. Four holes were drilled at Site 810. Hole 810A consists of a single mud-line core for an ongoing ODP geriatric study. The second hole (Hole 810B) was washed to 60 mbsf (without core recovery) to provide information required for setting the 16-in. casing attached to the reentry cone. Hole 810C penetrated 136.1 mbsf, mostly with the APC, with a total recovery of 143.81 m of nannofossil ooze. A reentry cone was placed over Hole 810D but no casing was successfully suspended in the hole and no sediment was cored. This data report presents the results of shore-based high-resolution analyses of carbonate and oxygen isotopic variations in the upper 50 m of the section at Site 810 and compares these variations with the shipboard determinations of magnetic susceptibility and GRAPE bulk density from the multisensor track.

Diário da Constituinte [gravação de vídeo] : [programa n. 132]

Relatores Adjuntos da Comissão de Sistematização cumpriram o prazo e entregaram a revisão final das emendas ao anteprojeto de Constituição ao Presidente da Comissão Afonso Arinos (PFL-RJ). José Ignácio Ferreira (PMDB-ES) explica como foi minuciosa a análise das emendas. O PMDB, o PFL e o PDT fecharam acordo para aprovar o parecer sobre as emendas, sem admissão de destaques. Adolfo Oliveira (PL-RJ) diz que o anteprojeto receberá milhares de contribuições e vai merecer um estudo criterioso por parte do Relator Bernardo Cabral para o preparo de um projeto que some as propostas das comissões temáticas com as do Plenário. Vivaldo Barbosa (PDT-RJ) ressalta que, durante os próximos trinta dias, a sociedade como um todo e os constituintes poderão enviar suas emendas e espera que desse trabalho conjunto se possa produzir uma Constituição capaz de promover a democracia e a justiça social no país. Na sessão O Povo Pergunta, cidadão quer saber como os constituintes estão fazendo para a melhoria dos transportes públicos. Átila Lira (PFL-PI) responde que a Constituição tratará de princípios em relação ao sistema de transporte, como um serviço público de responsabilidade do Estado, podendo ser explorado diretamente ou por concessão à iniciativa privada. A Comissão de Sistematização da Assembleia Nacional Constituinte (ANC) reuniu-se extraordinariamente para votar dois projetos de decisão. O primeiro sobre a dívida externa e o outro sobre a transmissão obrigatória de todas as votações plenárias pelo rádio e televisão. Artur da Távola (PMDB-RJ) não considera que impor ao telespectador a transmissão obrigatória de todas as sessões seja a melhor solução, mas sugere que o tempo do programa Diário da Constituinte possa ser ampliado, de tal forma que seja transmitido o resumo dos trabalhos. Plínio de Arruda Sampaio (PT-SP) defende o projeto de decisão.

MicroRNA-132 is a physiological regulator of hematopoietic stem cell function and B-cell development

MicroRNAs are a class of small non-coding RNAs that negatively regulate gene expression. Several microRNAs have been implicated in altering hematopoietic cell fate decisions. Importantly, deregulation of many microRNAs can lead to deleterious consequences in the hematopoietic system, including the onset of cancer, autoimmunity, or a failure to respond effectively to infection. As such, microRNAs fine-tune the balance between normal hematopoietic output and pathologic consequences. In this work, we explore the role of two microRNAs, miR-132 and miR-125b, in regulating hematopoietic stem cell (HSC) function and B cell development. In particular, we uncover the role of miR-132 in maintaining the appropriate balance between self-renewal, differentiation, and survival in aging HSCs by buffering the expression of a critical transcription factor, FOXO3. By maintain this balance, miR-132 may play a critical role in preventing aging-associated hematopoietic conditions such as autoimmune disease and cancer. We also find that miR-132 plays a critical role in B cell development by targeting a key transcription factor, Sox4, that is responsible for the differentiation of pro-B cells into pre-B cells. We find that miR-132 regulates B cell apoptosis, and by delivering miR-132 to mice that are predisposed to developing B cell cancers, we can inhibit the formation of these cancers and improve the survival of these mice. In addition to miR-132, we uncovered the role of another critical microRNA, miR-125b, that potentiates hematopoietic stem cell function. We found that enforced expression of miR-125b causes an aggressive myeloid leukemia by downregulation of its target Lin28a. Importantly, miR-125b also plays a critical role in inhibiting the formation of pro-B cells. Thus, we have discovered two microRNAs with important roles in regulating normal hematopoiesis, and whose dregulation can lead to deleterious consequences such as cancer in the aging hematopoietic system. Both miR-132 and miR-125b may therefore be targeted for therapeutics to inhibit age-related immune diseases associated with the loss of HSC function and cancer progression.