1 resultado para ddc:760
em Universidade de Lisboa - Repositório Aberto
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (2)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (2)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (1)
- Aquatic Commons (3)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archive of European Integration (6)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (3)
- Biblioteca Digital da Câmara dos Deputados (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (20)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (8)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (3)
- Bibloteca do Senado Federal do Brasil (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (19)
- Boston University Digital Common (1)
- Brock University, Canada (2)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (1)
- Cámara de Comercio de Bogotá, Colombia (1)
- Cambridge University Engineering Department Publications Database (18)
- CentAUR: Central Archive University of Reading - UK (18)
- Central European University - Research Support Scheme (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (73)
- Cochin University of Science & Technology (CUSAT), India (4)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (6)
- CUNY Academic Works (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (6)
- Department of Computer Science E-Repository - King's College London, Strand, London (1)
- Digital Commons - Michigan Tech (1)
- Digital Peer Publishing (102)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Duke University (4)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (3)
- Fachlicher Dokumentenserver Paedagogik/Erziehungswissenschaften (44)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (10)
- Greenwich Academic Literature Archive - UK (3)
- Helda - Digital Repository of University of Helsinki (3)
- Indian Institute of Science - Bangalore - Índia (38)
- Instituto Politécnico do Porto, Portugal (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (4)
- Ministerio de Cultura, Spain (29)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (6)
- Publishing Network for Geoscientific & Environmental Data (4)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (24)
- Queensland University of Technology - ePrints Archive (33)
- Repositório digital da Fundação Getúlio Vargas - FGV (4)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- REPOSITORIO DIGITAL IMARPE - INSTITUTO DEL MAR DEL PERÚ, Peru (1)
- Repositorio Institucional de la Universidad Nacional Agraria (3)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (97)
- Royal College of Art Research Repository - Uninet Kingdom (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- SerWisS - Server für Wissenschaftliche Schriften der Fachhochschule Hannover (317)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad del Rosario, Colombia (18)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (4)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universitat de Girona, Spain (3)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (2)
- Université de Lausanne, Switzerland (4)
- Université de Montréal, Canada (6)
- University of Michigan (6)
- University of Southampton, United Kingdom (2)
Resumo:
The phytochemical study of Euphorbia piscatoria yielded jolkinol D (1) in a large amount, whose derivatization gave rise to 12 ester derivatives (2–13) and hydrolysis to compound 14. The in vitro modulation of P-gp of compounds 1–14 was evaluated through a combination of transport and chemosensitivity assays, using the L5178 mouse T lymphoma cell line transfected with the human MDR1 gene. Apart from jolkinol D, all derivatives (2–14) showed potential as MDR reversal agents. In this small library of novel bioactive macrocyclic lathyrane diterpene derivatives, designed to evaluate structure–activity relationships essential in overcoming multidrug resistance (MDR), some correlations between MDR reversal and molecular weight, accessible solvent areas, and octanol/water partition coefficient were identified that can contribute to the development of new selective P-gp reversal agents.