Key Participants Of The Tumor Microenvironment Of The Prostate: An Approach Of The Structural Dynamic Of Cellular Elements And Extracellular Matrix Components During Epithelial-stromal Transition.

Cancer is a multistep process that begins with the transformation of normal epithelial cells and continues with tumor growth, stromal invasion and metastasis. The remodeling of the peritumoral environment is decisive for the onset of tumor invasiveness. This event is dependent on epithelial-stromal interactions, degradation of extracellular matrix components and reorganization of fibrillar components. Our research group has studied in a new proposed rodent model the participation of cellular and molecular components in the prostate microenvironment that contributes to cancer progression. Our group adopted the gerbil Meriones unguiculatus as an alternative experimental model for prostate cancer study. This model has presented significant responses to hormonal treatments and to development of spontaneous and induced neoplasias. The data obtained indicate reorganization of type I collagen fibers and reticular fibers, synthesis of new components such as tenascin and proteoglycans, degradation of basement membrane components and elastic fibers and increased expression of metalloproteinases. Fibroblasts that border the region, apparently participate in the stromal reaction. The roles of each of these events, as well as some signaling molecules, participants of neoplastic progression and factors that promote genetic reprogramming during epithelial-stromal transition are also discussed.

Do gênio da língua ao tradutor como gênio

The article presents two translation models that were typical in the XVII and XVIII centuries, but can also be seen as paradigmatics in the field of Translation Studies: 1) The rhetorical model that defends the possibility of translation and emphasizes the necessity of adapting the original to the taste of the target public. 2) The model that affirms the impossibility of translation, the non-translatability: a) because the sensual elements that are linked to the language of the original are praised; b) because there is a defense of the cultural relativism and of the non-translatability between cultures; c) or because there is a defense not only of the impossibility to separate signifiers and meaning, but also because there is a definition of the signifier and of all identities as being the result of a differential game.

Adaptação do handebol para a prática em cadeira de rodas

Universidade Estadual de Campinas . Faculdade de Educação Física

O jogo de futebol : investigação de sua estrutura, de seus modelos e da inteligencia de jogo, do ponto de vista da complexidade

Universidade Estadual de Campinas . Faculdade de Educação Física

As relações de gênero em uma escola de futebol : quando o jogo é possível? = Genders relations at a football school : when the game happen?

Universidade Estadual de Campinas . Faculdade de Educação Física