Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity

Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial resolution and sensitivity. Multipinhole, coded mask- and slit-based collimators are presented as alternative approaches to improve image quality. In combination with appropriate decoding algorithms, these collimators permit a significant reduction of the time needed to register the projections used to make 3-D representations of the volumetric distribution of target’s radiotracers. Simultaneously, they can be used to minimize artifacts and blurring arising when single pinhole collimators are used. Representation images are presented, which illustrate the use of these collimators. We also comment on the use of coded masks to attain tomographic resolution with a single projection, as discussed by some investigators since their introduction to obtain near-field images. We conclude this review by showing that the use of appropriate hardware and software tools adapted to conventional gamma-cameras can be of great help in obtaining relevant functional information in experiments using small animals.

Software CMAP TOOLS® para a construção de mapas conceituais: a avaliação dos estudantes de enfermagem

O mapeamento conceitual (MC) é uma estratégia de ensino que pode ser utilizada para resoluções de casos clínicos, porém de trabalhosa execução manuscrita. O estudo teve por objetivos descrever os desafios e as contribuições do software Cmap Tools® para a construção de mapas conceituais para resolução de caso clínico. Para isso, utilizou-se método descritivo, qualitativo, com estudantes da 3ª série de Graduação em Enfermagem da Universidade Federal de São Paulo. A estratégia de ensino foi aplicada e os dados foram coletados pela técnica do grupo focal. Os resultados evidenciaram que o software facilita e garante a organização, visualização e correlação dos dados, porém com dificuldades iniciais relacionadas ao manejo das ferramentas que dispõe. Concluiu-se que o software Cmap Tools® favoreceu a construção dos MC por seus recursos de formatação e autoformatação e que estratégias de orientação deveriam ser implantadas para a fase inicial de utilização.

Spatial distribution of dengue in the city of Cruzeiro, São Paulo State, Brazil: use of geoprocessing tools

The aim of this article is to identify patterns in spatial distribution of cases of dengue fever that occurred in the municipality of Cruzeiro, State of São Paulo, in 2006. This is an ecological and exploratory study using the tools of spatial analysis in the preparation of thematic maps with data from Sinan-Net. An analysis was made by area, taking as unit the IBGE census, the analysis included four months in 2006 which show the occurrence of the disease in the city. The thematic maps were constructed by TerraView 3.3.1 software, the same software provided the values of the indicators of Global Moran (I M) every month and the Kernel estimation. In the year 2006, 691 cases of dengue were georeferenced (with a rate of 864.2 cases/100,000 inhabitants); the indicators of Moran and p-values obtained were I M = 0.080 (March) p = 0.11; I M = 0.285 (April) p = 0.01; I M = 0.201 (May) p = 0.01 and I M = 0.002 (June) p = 0.57. The first cases were identified in the Northeast and Central areas of Cruzeiro and the recent cases, in the North, Northeast and Central. It was possible to identify census tracts where the epidemic began and how it occurred temporally and spatially in the city.

Computer tools applied to analysis of solar water heaters

The simulation programs are important tools to analyze the different energetic alternatives, including the use of renewable energy. The objective of this study was to analyze comparatively the different computer tools available for modeling of solar water heaters. Among the main simulation software of solar thermal systems, there are: RETScreen International, EnergyPlus, TRNSYS, SolDesigner, SolarPro, e T*SOL. Among the tools mentioned, only EnergyPlus and RETScreen International are free, but they allow obtaining interesting results when applied together. The first one has a detailed module of energy analysis of solar water heaters, while the second one provides an detailed economic feasibility study and an assessment of emissions of greenhouse gases. RETScreen International and EnergyPlus programs are aimed at a diverse audience, including designers, researchers and energy planners.

Object-oriented Programming Applied to the Development of Structural Analysis and Optimization Software

This paper presents the development of a two-dimensional interactive software environment for structural analysis and optimization based on object-oriented programming using the C++ language. The main feature of the software is the effective integration of several computational tools into graphical user interfaces implemented in the Windows-98 and Windows-NT operating systems. The interfaces simplify data specification in the simulation and optimization of two-dimensional linear elastic problems. NURBS have been used in the software modules to represent geometric and graphical data. Extensions to the analysis of three-dimensional problems have been implemented and are also discussed in this paper.

Analysis of open CNC architecture for machine tools

The evolution of digital circuit technology, leadind to higher speeds and more reliability allowed the development of machine controllers adapted to new production systems (e.g., Flexible Manufacturing Systems - FMS). Most of the controllers are developed in agreement with the CNC technology of the correspondent machine tool manufacturer. Any alterations or adaptation of their components are not easy to be implemented. The machine designers face up hardware and software restrictions such as lack of interaction among system's elements and impossibility of adding new function. This is due to hardware incompatibility and to software not allowing alterations in the source program. The introduction of open architecture philosophy propitiated the evolution of a new generation of numeric controllers. This brought the conventional CNC technology to the standard IBM - PC microcomputer. As a consequence, the characteristics of the CNC (positioning) and the microcomputer (easy of programming, system configuration, network communication etc) are combined. Some researchers have addressed a flexible structure of software and hardware allowing changes in the hardware basic configuration and all control software levels. In this work, the development of open architecture controllers in the OSACA, OMAC, HOAM-CNC and OSEC architectures is described.

Uso do software Estradas para determinação do espaçamento entre desaguadouros em estradas não pavimentadas do interior de Goiás

Estradas não pavimentadas correspondem a aproximadamente 90% da malha rodoviária brasileira. Estas, na maioria das vezes, são construídas sem a realização de estudos prévios, estando sujeitas a vários tipos de problemas. Um dos principais fatores de deterioração dessas vias é a ineficiência do sistema de drenagem. Neste trabalho simulou-se o espaçamento entre desaguadouros em estradas não pavimentadas, utilizando-se um software desenvolvido com base num modelo matemático de dimensionamento de sistemas de drenagem em estradas não pavimentadas. Utilizaram-se valores de erodibilidade, tensão crítica de cisalhamento e massa específica para diferentes solos de estradas, localizadas no Estado de Goiás. Simularam-se cenários considerando alterações na declividade (1, 5, 10 e 15%) e na seção transversal do canal com relações entre altura e largura de 1:1, 1:2, 1:5 e 1:10. O modelo respondeu sensivelmente às alterações na declividade, na seção transversal do canal e nas de resistência do solo. Os espaçamentos obtidos indicaram que, estradas com declividades inferiores a 5%, mesmo com elevados valores de erodibilidade permitiram espaçamentos viáveis em aspectos construtivos. No entanto, para as declividades de 10 e 15%, os espaçamentos, na maioria dos casos, apresentaram dimensões reduzidas, tornando-se impraticáveis, sendo necessário, nestes casos, proteção do canal ou alteração de suas características hidráulicas.

Dinâmica da acumulação de capacidades inovadoras: evidências de empresas de software no Rio de janeiro e em São Paulo

São escassos estudos sobre a dinâmica da acumulação de capacidades inovadoras. Este artigo examina o tema em oito empresas de software em São Paulo e Rio de Janeiro, encontrando: diferenças inter e intraempresariais em termos da direção e taxa de acumulação de capacidade para funções tecnológicas específicas; acúmulo de capacidade tecnológica mais rápido em empresas mais jovens; e decréscimo das taxas de acumulação tecnológica à medida que as empresas se aproximam de níveis mais inovadores de capacidades, demonstrando a potencialidade para aceleração do processo. Tais evidências são relevantes para o entendimento da acumulação tecnológica e fornecem uma noção do tempo necessário para se obterem benefícios de esforços de aprendizagem e construção de capacidade inovadora.

Atratividade de projetos de software livre: importância teórica e estratégias para administração

Milhares de Projetos de Software Livre (PSL) foram e continuam sendo criados na Internet. Esse cenário aumenta as oportunidades de colaboração tanto quanto acirra a concorrência por usuários e contribuidores, que elevariam esses projetos a níveis superiores aos que seriam alcançados por seus fundadores sozinhos. E dado que o aprimoramento por meio de colaboração é o principal objetivo dos fundadores de PSL, a importância de entender e administrar a capacidade de atrair usuários e contribuidores fica estabelecida. Para auxiliar pesquisadores e fundadores nesse desafio, o conceito de atratividade é introduzido neste artigo, que desenvolve um ferramental teórico-gerencial sobre as causas, indicadores e consequências da atratividade, viabilizando sua administração estratégica.

Knowledge cities: a taxonomy for analyzing software and information service clusters

Software and information services (SIS) have become a field of increasing opportunities for international trade due to the worldwide diffusion of a combination of technological and organizational innovations. In several regions, the software industry is organized in clusters, usually referred to as "knowledge cities" because of the growing importance of knowledge-intensive services in their economy. This paper has two primary objectives. First, it raises three major questions related to the attractiveness of different cities in Argentina and Brazil for hosting software companies and to their impact on local development. Second, a new taxonomy is proposed for grouping clusters according to their dominant business segment, ownership pattern and scope of operations. The purpose of this taxonomy is to encourage further studies and provide an exploratory analytical tool for analyzing software clusters.

PROPOSTA DE INVESTIGAÇÃO SOBRE O USO DE SOFTWARE NO SUPORTE À INOVAÇÃO EM SERVIÇOS

RESUMOEste artigo examina os objetivos, instrumentos e características das inovações habilitadas por Tecnologias da Informação e Comunicação (TICs) no Brasil, enfatizando as tecnologias utilizadas, os canais habilitados pelas ferramentas digitais, os processos de aprendizado para inovação e as mudanças organizacionais necessárias para o uso de ferramentas avançadas. A metodologia consiste na adaptação de taxonomias existentes para os propósitos específicos da pesquisa e a realização de uma pesquisa de campo com o auxílio do software Atlas.ti. Os resultados mostram que as inovações habilitadas por TIC não constituem eventos isolados e pontuais, uma vez que alteram processos, formas de relacionamento com parceiros e clientes, e requerem uma maior integração de funções organizacionais. Importantes diferenças foram observadas em função do porte da empresa, da internacionalização das operações, da capacitação técnica e do grau de acesso a ferramentas proprietárias.

BASS 4: a software system for ergonomic design and evaluation of working hours

OBJECTIVE: To extend an existing computer programme for the evaluation and design of shift schedules (BASS 3) by integrating workload as well as economic aspects. METHODS: The redesigned prototype BASS 4 includes a new module with a suitable and easily applicable screening method (EBA) for the assessment of the intensity of physical, emotional and cognitive workload components and their temporal patterns. Specified criterion functions based on these ratings allow for an adjustment of shift and rest duration according to the intensity of physical and mental workload. Furthermore, with regard to interactive effects both workload and temporal conditions, e.g. time of day, are taken into account. In a second new module, important economic aspects and criteria have been implemented. Different ergonomic solutions for scheduling problems can now also be evaluated with regard to their economic costs. RESULTS: The new version of the computer programme (BASS 4) can now simultaneously take into account numerous ergonomic, legal, agreed and economic criteria for the design and evaluation of working hours. CONCLUSIONS: BASS 4 can now be used as an instrument for the design and the evaluation of working hours with regard to legal, ergonomic and economic aspects at the shop floor as well as in administrative (e.g. health and safety inspection) and research problems.

Biotyping, serotyping and ribotyping as epidemiological tools in the evaluation of Acinetobacter baumannii dissemination in hospital units, Sorocaba, São Paulo, Brazil

Dissemination of Acinetobacter baumannii strains in different units of a hospital in Sorocaba, São Paulo, Brazil was evaluated over a period of two years. By using biotyping, serotyping and ribotyping, 27 distinct clones were differentiated among 76 strains isolated between 1993-94, from clinical specimens of hospitalized patients. Two clones, 2:O4:A (biotype:serotype:ribotype) and 2:O29:A accounted for the majority of strains widely disseminated in the units during 1993. The introduction in the hospital setting, of a new clone, 6:O13:B, at the end of 1993 and its predominance through 1994 is discussed. Among 15 strains isolated from neonates, 6 (40%) belonged to the same clone, 2:O4:A. Interestingly, this clone was almost all recovered in neonatal intensive care unit, nursery and in pediatric unit. All strains were susceptible to imipenem and polymyxcin B. Multiresistant strains (up to 12 antimicrobial agents) accounted for 66.7% and 84.8% of the strains isolated in 1993 and in 1994, respectively.

Software for pattern recognition of the larvae of Aedes aegypti and Aedes albopictus

Software for pattern recognition of the larvae of mosquitoes Aedes aegypti and Aedes albopictus, biological vectors of dengue and yellow fever, has been developed. Rapid field identification of larva using a digital camera linked to a laptop computer equipped with this software may greatly help prevention campaigns.