Ambiente de qualidade em uma biblioteca universitária: aplicação do 5S e de um estilo participativo de administração

O artigo divide-se em duas partes. A primeira analisa o Programa 5S de administração, nascido no Japão no final da década de 60, e o estilo participativo de gerenciamento organizacional. A segunda parte apresenta, a partir desta análise, uma experiência de aplicação conjunta destas duas formas de gestão em uma biblioteca universitária. Procura-se demonstrar que é possível, em um contexto de recursos escassos, encontrar soluções originais, alcançando significativa melhoria na prestação dos serviços aos usuários e criando um clima de confiança, responsabilidade e qualidade no local de trabalho.

Periódicos eletrônicos sobre administração disponíveis no portal de periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior: uma avaliação

Este trabalho analisa o conjunto de periódicos eletrônicos de administração disponíveis no Portal Capes, do ponto de vista dos interesses dos usuários de uma biblioteca universitária especializada no assunto. Empregou-se como método a análise das citações dos periódicos utilizados nas teses de doutorado defendidas no Programa de Pós-Graduação em Administração da Escola de Administração da Universidade Federal do Rio Grande do Sul no período 1999-2007. Observou-se que 25% dos periódicos citados nas teses não estão disponíveis no Portal e que os periódicos disponíveis apresentam limitações quanto à integralidade da coleção.

Nuevos fármacos inspirados en Annonáceas

Los metabolitos secundarios activos (MSA) juegan un papel importante en el descubrimiento de nuevos medicamentos. Moléculas naturales con esqueletos complejos, tales como las estatinas aisladas de Aspergillus terreus, o las acetogeninas específicas de la familia Annonaceae, no hubieran podido ser inventadas en ningún laboratorio. Los MSA aislados en Annonaceae, especialmente las acetogeninas y los alcaloides isoquinoleínicos, pueden ser considerados como fuente constante de inspiración para químicos, farmacólogos y para todos los investigadores interesados en el descubrimiento de una nueva familia de medicamentos.

Modelagem Molecular: Uma Ferramenta para o Planejamento Racional de Fármacos em Química Medicinal

The molecular basis of modern therapeutics consist in the modulation of cell function by the interaction of microbioactive molecules as drug cells macromolecules structures. Molecular modeling is a computational technique developed to access the chemical structure. This methodology, by means of the molecular similarity and complementary paradigm, is the basis for the computer-assisted drug design universally employed in pharmaceutical research laboratories to obtain more efficient, more selective, and safer drugs. In this work, we discuss some methods for molecular modeling and some approaches to evaluate new bioactive structures in development by our research group.

Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais

The thalidomide disaster, in the 60,s, is the most painful reminder of the importance of chirality for biological activity. After this episode, much attention has been devoted to study the correlations between toxicological and pharmacological properties and chirality. Actualy, to get a licence for a new chiral drug in EUA, European community and Japan, it is necessary to study the biological properties of each enatiomer independently. This article presents an overview about the importance of the chirality of organic compounds and its relationships with biological activity, asymmetric synthetic methodologies and market.

Os fármacos e a quiralidade: uma breve abordagem

The concepts of stereochemistry and chirality are introduced, and the ability to distinguish among the different receptors caused by one stereoselective action against chiral drugs is presented. The importance of the behaviour of chiral drugs is emphasized.

Determinação espectrofotométrica de ácido ascórbico em fármacos empregando amostragem binária em fluxo

A flow system procedure for spectrophotometric determination of ascorbic acid in drugs based on [Fe3+(SCN-)n]+3-n complex decomposition by reduction is described. The flow network was constituted by a set of three-way solenoid valves, controlled by a microcomputer running a software wrote in QuickBasic 4.5 language. The feasibility of the procedure was ascertained by determining ascorbic acid in drug samples with mass ranging from 0.0018 up to 0.0180 g. The results showed an agreement of about 7% when compared with recommended method. Other profitable features such as a standard deviation of 1.5% (n = 7) and a throughput of 120 determinations per hour was also achieved.

O processo de latenciação no planejamento de fármacos

Short review about the main aspects of prodrug design, as its objectives, applicability and importance, showing the new trends in the research for selective latent forms, namely targeted drugs.

Caracterização de polimorfismo em fármacos por ressonância magnética nuclear no estado sólido

This review aims to present some features about solid state NMR and its application in the field of pharmaceutical chemistry, for the characterization of polymorphism of pharmaceutical molecules.

Planejamento racional de fármacos baseado em produtos naturais

In the area of drug discovery, natural products represent a myriad of templates for new lead discovery. It is, however, most unlikely that the bioactive principle itself shall become a drug; it is much more likely that a medicinal chemistry project needs to be initiated as soon the potency or selectivity or specificity of the new natural product candidate has been disclosed. Brazil has an enormous biodiversity where just a few has been disclosed. Nevertheless, it urges to initiate a joint collaboration in order to circumvent a major breakdown linking between natural products and medicinal chemistry in this country. This paper is intended to encourage people to follow up one of the most pushing forward enterprise that needs to be settled: the pharmaceutical industry.

Fármacos e fitoterápicos: a necessidade do desenvolvimento da indústria de fitoterápicos e fitofármacos no Brasil

We discuss briefly the development and the present status of medicinal chemistry. In this context, we consider the therapeutic possibilities of the phytotherapy. On the basis of this analysis, the development of the phytopharmaceutical industry in Brazil is shown to be of essential importance for both the university and the Country due to the human and technological resources involved.

Aplicações da química combinatória no desenvolvimento de fármacos

Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead compounds. This article gives an overview of the principal characteristics of combinatorial libraries and some examples of the application of this methodology in the identification of test compounds and lead compound optimization, either from synthetic or natural sources.

A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos

In this article are described new bioactive N-acylhydrazone (NAH) derivatives, structurally designed as optimization of aryl hydrazones precursors planned by molecular hybridization of two 5-lipoxigenase inhibitors, e.g. CBS-1108 and BW-755c. The analgesic, antiedematogenic and anti-platelet aggregating profile of several isosteric compounds was investigated by using classic pharmacological assays in vivo and ex-vivo, allowing to identify new potent peripheric analgesic lead, a new anti-inflammatory and an antithrombotic agent. During this study was discovered dozen of active NAH compounds clarifying the structure-activity relationship for this series of NAH derivatives, indicating the pharmacophore character of the N-acylhydrazone functionality.