1 resultado para colony
em Bioline International
Filtro por publicador
- Aberdeen University (2)
- Abertay Research Collections - Abertay University’s repository (1)
- Aberystwyth University Repository - Reino Unido (9)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (3)
- Aquatic Commons (14)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (2)
- Avian Conservation and Ecology - Eletronic Cientific Hournal - Écologie et conservation des oiseaux: (5)
- Biblioteca Digital da Câmara dos Deputados (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (27)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (25)
- Biodiversity Heritage Library, United States (1)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (35)
- Brock University, Canada (28)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (58)
- Center for Jewish History Digital Collections (13)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (35)
- Cochin University of Science & Technology (CUSAT), India (4)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Dalarna University College Electronic Archive (7)
- Deakin Research Online - Australia (40)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (5)
- Digital Archives@Colby (1)
- Digital Commons - Montana Tech (1)
- Digital Commons at Florida International University (5)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (2)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (2)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (13)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (16)
- Greenwich Academic Literature Archive - UK (1)
- Harvard University (7)
- Helda - Digital Repository of University of Helsinki (16)
- Indian Institute of Science - Bangalore - Índia (71)
- Instituto Gulbenkian de Ciência (1)
- Instituto Politécnico do Porto, Portugal (3)
- Massachusetts Institute of Technology (1)
- National Center for Biotechnology Information - NCBI (30)
- Nottingham eTheses (3)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (10)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (28)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (117)
- Queensland University of Technology - ePrints Archive (79)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (3)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (1)
- Repositorio Institucional de la Universidad de Almería (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (40)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
- Universidad del Rosario, Colombia (10)
- Universidad Politécnica de Madrid (8)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (4)
- Universidade Federal do Rio Grande do Norte (UFRN) (2)
- Universitat de Girona, Spain (2)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (8)
- Université de Montréal, Canada (30)
- University of Canberra Research Repository - Australia (2)
- University of Michigan (106)
- University of Queensland eSpace - Australia (15)
- University of Washington (1)
- WestminsterResearch - UK (5)
Resumo:
T-cell based vaccines against human immunodeficiency virus (HIV) generate specific responses that may limit both transmission and disease progression by controlling viral load. Broad, polyfunctional, and cytotoxic CD4+ T-cell responses have been associated with control of simian immunodeficiency virus/HIV-1 replication, supporting the inclusion of CD4+ T-cell epitopes in vaccine formulations. Plasmid-encoded granulocyte-macrophage colony-stimulating factor (pGM-CSF) co-administration has been shown to induce potent CD4+ T-cell responses and to promote accelerated priming and increased migration of antigen-specific CD4+ T-cells. However, no study has shown whether co-immunisation with pGM-CSF enhances the number of vaccine-induced polyfunctional CD4+ T-cells. Our group has previously developed a DNA vaccine encoding conserved, multiple human leukocyte antigen (HLA)-DR binding HIV-1 subtype B peptides, which elicited broad, polyfunctional and long-lived CD4+ T-cell responses. Here, we show that pGM-CSF co-immunisation improved both magnitude and quality of vaccine-induced T-cell responses, particularly by increasing proliferating CD4+ T-cells that produce simultaneously interferon-γ, tumour necrosis factor-α and interleukin-2. Thus, we believe that the use of pGM-CSF may be helpful for vaccine strategies focused on the activation of anti-HIV CD4+ T-cell immunity.