1 resultado para HUMAN-BLOOD-PLASMA
em Bioline International
Filtro por publicador
- Repository Napier (1)
- Aberdeen University (3)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- Adam Mickiewicz University Repository (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (5)
- Aquatic Commons (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (12)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (10)
- Aston University Research Archive (20)
- Biblioteca de Teses e Dissertações da USP (4)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (31)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (17)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (5)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (94)
- Boston University Digital Common (1)
- Brock University, Canada (1)
- Cambridge University Engineering Department Publications Database (7)
- CentAUR: Central Archive University of Reading - UK (34)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (62)
- CiencIPCA - Instituto Politécnico do Cávado e do Ave, Portugal (1)
- Cochin University of Science & Technology (CUSAT), India (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Deakin Research Online - Australia (31)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (8)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (5)
- Digital Howard @ Howard University | Howard University Research (2)
- DigitalCommons@The Texas Medical Center (16)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (19)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (4)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Greenwich Academic Literature Archive - UK (3)
- Helda - Digital Repository of University of Helsinki (34)
- Indian Institute of Science - Bangalore - Índia (26)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (3)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico de Bragança (1)
- Instituto Politécnico do Porto, Portugal (1)
- National Center for Biotechnology Information - NCBI (45)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (12)
- QSpace: Queen's University - Canada (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (69)
- Queensland University of Technology - ePrints Archive (152)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Federal de São Paulo - UNIFESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (99)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- Universidad del Rosario, Colombia (1)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal do Pará (5)
- Universidade Federal do Rio Grande do Norte (UFRN) (8)
- Universitat de Girona, Spain (2)
- Université de Lausanne, Switzerland (5)
- Université de Montréal (2)
- Université de Montréal, Canada (9)
- University of Connecticut - USA (2)
- University of Michigan (8)
- University of Queensland eSpace - Australia (36)
- WestminsterResearch - UK (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Purpose: To develop a micelle-enhanced spectrofluorimetric method for the assay of azilsartan (AZL) in bulk form and spiked human plasma without the need for derivatization procedure. Method: The proposed method was based on studying the fluorescence behavior of AZL in Cremophor RH 40 (Cr RH 40) micellar system. The fluorescence intensity was measured at 371 nm after excitation at 264 nm. The proposed procedure was validated according to International Council on Harmonization (ICH) guidelines. Results: In aqueous solution, the fluorescence intensity of AZL was greatly enhanced by more than 3- fold in the presence of Cr RH 40. The fluorescence –concentration plot was linear over the range of 10 – 500 ng.mL-1, with a limit of detection of 3.287 ngmL-1. The proposed method was successfully applied to the determination of AZL in pure powder form and spiked human plasma. The mean recovery of AZL in spiked human plasma using the proposed method was 90.54 ± 1.17 %. Conclusion: The suggested method is highly sensitive and simple, and can easily be applied for the quantification of AZL in pure powder form as well as in biological fluids such as plasma.