Narrative comprehension: Semantic and syntactic summary production

The purpose of this research was to examine from a syntactic and narrative structure perspective two narrative summary types: a summary with a length constraint and an unconstrained summary. In addition, this research served to develop a multidimensional theory of narrative comprehension.^ College freshmen read two short stories written by written by Sake and were asked to write a constrained summary for one text and an unconstrained summary for the other text. Following this the subjects completed a metacognitive questionnaire. The summaries were analyzed to examine transitivity features and narrative structure features. The metacognitive questionnaires were examined to extract information about plot structure, differences between one and two episode stories, and to gain insight into the strategies used by subjects in producing both summary types.^ A Paired t-test conducted on the data found that there was a significant transitivity feature mean difference between a constrained summary and an unconstrained summary indicating that the number of transitivity features produced from each summary type were task dependent.^ Chi-square tests conducted on the data found that there were proportional differences in usage between plot features and thematic abstract units in an unconstrained summary and a constrained summary indicating that plot features and thematic abstract units produced from each summary type were task dependent.^ Qualitative analyses indicated that setting, goal, and resolution are typical within plot organization, there are summary production differences between one and two episode narratives, and subjects do not seem to be aware of summary production strategies.^ The results of this research have implications for comprehension and writing instruction. ^

Development, validation and uncertainty analysis of quantitative structure and activity relationship models for Log P of disinfection by -products

Hydrophobicity as measured by Log P is an important molecular property related to toxicity and carcinogenicity. With increasing public health concerns for the effects of Disinfection By-Products (DBPs), there are considerable benefits in developing Quantitative Structure and Activity Relationship (QSAR) models capable of accurately predicting Log P. In this research, Log P values of 173 DBP compounds in 6 functional classes were used to develop QSAR models, by applying 3 molecular descriptors, namely, Energy of the Lowest Unoccupied Molecular Orbital (ELUMO), Number of Chlorine (NCl) and Number of Carbon (NC) by Multiple Linear Regression (MLR) analysis. The QSAR models developed were validated based on the Organization for Economic Co-operation and Development (OECD) principles. The model Applicability Domain (AD) and mechanistic interpretation were explored. Considering the very complex nature of DBPs, the established QSAR models performed very well with respect to goodness-of-fit, robustness and predictability. The predicted values of Log P of DBPs by the QSAR models were found to be significant with a correlation coefficient R2 from 81% to 98%. The Leverage Approach by Williams Plot was applied to detect and remove outliers, consequently increasing R 2 by approximately 2% to 13% for different DBP classes. The developed QSAR models were statistically validated for their predictive power by the Leave-One-Out (LOO) and Leave-Many-Out (LMO) cross validation methods. Finally, Monte Carlo simulation was used to assess the variations and inherent uncertainties in the QSAR models of Log P and determine the most influential parameters in connection with Log P prediction. The developed QSAR models in this dissertation will have a broad applicability domain because the research data set covered six out of eight common DBP classes, including halogenated alkane, halogenated alkene, halogenated aromatic, halogenated aldehyde, halogenated ketone, and halogenated carboxylic acid, which have been brought to the attention of regulatory agencies in recent years. Furthermore, the QSAR models are suitable to be used for prediction of similar DBP compounds within the same applicability domain. The selection and integration of various methodologies developed in this research may also benefit future research in similar fields.