Mutation at the Human D1S80 Minisatellite Locus

Little is known about the general biology of minisatellites. The purpose of this study is to examine repeat mutations from the D1S80 minisatellite locus by sequence analysis to elucidate the mutational process at this locus. This is a highly polymorphic minisatellite locus, located in the subtelomeric region of chromosome 1. We have analyzed 90,000 human germline transmission events and found seven (7) mutations at this locus. The D1S80 alleles of the parentage trio, the child, mother, and the alleged father were sequenced and the origin of the mutation was determined. Using American Association of Blood Banks (AABB) guidelines, we found a male mutation rate of 1 . 0 4 × 1 0− 4 and a female mutation rate of 5 . 1 8 × 1 0− 5 with an overall mutation rate of approximately 7 . 7 7 × 1 0− 5. Also, in this study, we found that the identified mutations are in close proximity to the center of the repeat array rather than at the ends of the repeat array. Several studies have examined the mutational mechanisms of the minisatellites according to infinite allele model (IAM) and the one-step stepwise mutation model (SMM). In this study, we found that this locus fits into the one-step mutation model (SMM) mechanism in six out of seven instances similar to STR loci.

Japan in Crisis- an FIU Teach-In

Panel discussion on the subject of the March 2011 earthquake disaster in Japan featuring the following speakers: Steven Heine, Associate Director, SIPA; Director, Asian Studies Institute Dean Whitman, Associate Professor, Department fo Earth and Environment Richard Olson, Professor, Department of Politics and International Relations Joerg Reinhold, Associate Professor, Department of Physics Paul Kowert, Associate Professor, Department of Politics and International Relations Matthew Marr, Assistant Professor, Department of Global and Sociocultural Studies Pallab Mozumder, Assistant Professor, Department of Earth and Environment and Department of Economics Discussion was held at the Graham Center Ballroom of the Modesto A. Maidique Campus