Development of a personality profile of a firefighter

This study investigated the differences in personality, consistent with the vocational theory of personality as proposed by Holland (1997), for a modern day firefighter. This study also investigates the relationships between personality characteristics and job duties performed by firefighters and firefighter-paramedics. Archival data from employees (N = 98) of a Southeastern Florida fire department who completed the Hogan Personality Inventory (HPI), Hogan Development Survey (HDS) and Motives, Values, Preferences Inventory (MVPI), as well as a self-report questionnaire on variety proneness (boredom), job satisfaction, and affective well-being data were analyzed. The scores of the firefighters on the HPI, HDS, and MVPI were used as predictive data, and criterion data used in this study were self-report satisfaction data on job involvement, variety proneness (boredom), and affective well-being. In addition, criterion data on performance were obtained from the employment histories of the participants, and were correlated with the personality scale scores to determine if personality is predictive of aspects of performance. ^ Participants in this study varied with respect to the type of firefighter duties required from them on their jobs. The participants were categorized into three duty classifications: Group 1 (G1) are the firefighters hired before 1990 and are only certified as firefighters; Group 2 (G2) are the firefighters hired before 1990 who became paramedics at some point after employment and after fire college training; and Group 3 (G3) are the firefighters hired after 1990 who were trained as paramedics in the fire college and who were aware of the paramedic requirement at time of application or were already trained as paramedics at the time of application. From the research reviewed and presented in this paper, hypotheses were generated about differences between the personality types of firefighter groups G1 and G2 versus G3, in accordance with Holland's theories. In addition, it was hypothesized that personality will predict outcomes of satisfaction and performance. ^ Results found that job satisfaction was not found to be statistically different among the groups. However, the groups differed significantly on 5 of the predictive instrument scales, and personality was found to be a predictor of limited performance data. ^

Specific Increase in MDR1 Mediated Drug-Efflux in Human Brain Endothelial Cells following Co-Exposure to HIV-1 and Saquinavir

Persistence of HIV-1 reservoirs within the Central Nervous System (CNS) remains a significant challenge to the efficacy of potent anti-HIV-1 drugs. The primary human Brain Microvascular Endothelial Cells (HBMVEC) constitutes the Blood Brain Barrier (BBB) which interferes with anti-HIV drug delivery into the CNS. The ATP binding cassette (ABC) transporters expressed on HBMVEC can efflux HIV-1 protease inhibitors (HPI), enabling the persistence of HIV-1 in CNS. Constitutive low level expression of several ABC-transporters, such as MDR1 (a.k.a. P-gp) and MRPs are documented in HBMVEC. Although it is recognized that inflammatory cytokines and exposure to xenobiotic drug substrates (e.g HPI) can augment the expression of these transporters, it is not known whether concomitant exposure to virus and anti-retroviral drugs can increase drug-efflux functions in HBMVEC. Our in vitro studies showed that exposure of HBMVEC to HIV-1 significantly up-regulates both MDR1 gene expression and protein levels; however, no significant increases in either MRP-1 or MRP-2 were observed. Furthermore, calcein-AM dye-efflux assays using HBMVEC showed that, compared to virus exposure alone, the MDR1 mediated drug-efflux function was significantly induced following concomitant exposure to both HIV-1 and saquinavir (SQV). This increase in MDR1 mediated drug-efflux was further substantiated via increased intracellular retention of radiolabeled [3H-] SQV. The crucial role of MDR1 in 3H-SQV efflux from HBMVEC was further confirmed by using both a MDR1 specific blocker (PSC-833) and MDR1 specific siRNAs. Therefore, MDR1 specific drug-efflux function increases in HBMVEC following co-exposure to HIV-1 and SQV which can reduce the penetration of HPIs into the infected brain reservoirs of HIV-1. A targeted suppression of MDR1 in the BBB may thus provide a novel strategy to suppress residual viral replication in the CNS, by augmenting the therapeutic efficacy of HAART drugs.