Semantic wrapping for heterogeneous database management

Query processing is a commonly performed procedure and a vital and integral part of information processing. It is therefore important and necessary for information processing applications to continuously improve the accessibility of data sources as well as the ability to perform queries on those data sources. ^ It is well known that the relational database model and the Structured Query Language (SQL) are currently the most popular tools to implement and query databases. However, a certain level of expertise is needed to use SQL and to access relational databases. This study presents a semantic modeling approach that enables the average user to access and query existing relational databases without the concern of the database's structure or technicalities. This method includes an algorithm to represent relational database schemas in a more semantically rich way. The result of which is a semantic view of the relational database. The user performs queries using an adapted version of SQL, namely Semantic SQL. This method substantially reduces the size and complexity of queries. Additionally, it shortens the database application development cycle and improves maintenance and reliability by reducing the size of application programs. Furthermore, a Semantic Wrapper tool illustrating the semantic wrapping method is presented. ^ I further extend the use of this semantic wrapping method to heterogeneous database management. Relational, object-oriented databases and the Internet data sources are considered to be part of the heterogeneous database environment. Semantic schemas resulting from the algorithm presented in the method were employed to describe the structure of these data sources in a uniform way. Semantic SQL was utilized to query various data sources. As a result, this method provides users with the ability to access and perform queries on heterogeneous database systems in a more innate way. ^

A mathematical resolution to log transformations and the binning effect in applied processing of data in flow cytometry

This dissertation develops a new mathematical approach that overcomes the effect of a data processing phenomenon known as “histogram binning” inherent to flow cytometry data. A real-time procedure is introduced to prove the effectiveness and fast implementation of such an approach on real-world data. The histogram binning effect is a dilemma posed by two seemingly antagonistic developments: (1) flow cytometry data in its histogram form is extended in its dynamic range to improve its analysis and interpretation, and (2) the inevitable dynamic range extension introduces an unwelcome side effect, the binning effect, which skews the statistics of the data, undermining as a consequence the accuracy of the analysis and the eventual interpretation of the data. ^ Researchers in the field contended with such a dilemma for many years, resorting either to hardware approaches that are rather costly with inherent calibration and noise effects; or have developed software techniques based on filtering the binning effect but without successfully preserving the statistical content of the original data. ^ The mathematical approach introduced in this dissertation is so appealing that a patent application has been filed. The contribution of this dissertation is an incremental scientific innovation based on a mathematical framework that will allow researchers in the field of flow cytometry to improve the interpretation of data knowing that its statistical meaning has been faithfully preserved for its optimized analysis. Furthermore, with the same mathematical foundation, proof of the origin of such an inherent artifact is provided. ^ These results are unique in that new mathematical derivations are established to define and solve the critical problem of the binning effect faced at the experimental assessment level, providing a data platform that preserves its statistical content. ^ In addition, a novel method for accumulating the log-transformed data was developed. This new method uses the properties of the transformation of statistical distributions to accumulate the output histogram in a non-integer and multi-channel fashion. Although the mathematics of this new mapping technique seem intricate, the concise nature of the derivations allow for an implementation procedure that lends itself to a real-time implementation using lookup tables, a task that is also introduced in this dissertation. ^