Análise da expressão dos receptores HER-2 e sua correlação clínica em pacientes com neoplasia gástrica do setor de Oncologia do Hospital de Clínicas da Universidade Federal de Uberlândia-UFU

Introduction: Gastric cancer is currently the fourth higher cancer mortality rate among men in the world and the fifth among women, despite the progressive advances in oncology. The identification of tumor receptors and the development of target-drugs to block them has contributed to increased survival and quality of life of patients, but it becomes important to know the tumor profile of the population being treated, avoiding burdening treatment with examinations and treatments that are not cost-effective. Objective: To evaluate the profile of the population with gastric cancer treated in five years at the Clinical Hospital of the Federal University of Uberlândia and verify the correlation between overexpression of HER-2 receptor with an unfavorable prognosis. Methods: 203 records with gastric cancer were selected through the system database, attending a five-year period, of which 117 paraffin blocks were available for immunohistochemical assessment of HER2 receptor. Results: 2.6% of tumors showed overexpression of HER2, considering for this study two crosses as positive. There was no statistically significant difference in correlation between expression of the HER2 receptor with age, gender, tumor grade, local involvement, Lauren classification, Borrmann classification or staging. Conclusion: For this studied population, we can conclude that there is no need to employ HER2 blockers with high cost as a target-therapy in patients with gastric cancer, since no clinical benefit probably will be obtained due to a low percentage of these patients that demonstrated superexpression of this receptor or even there is no patients with gastric cancer with superexpression of HER2 with more than three crosses of positivity in immunochemistry

Caminhos da professoralidade no Curso de Dança da UFU: impasses e desafios na construção da identidade profissional

Teacher identity is a subject of study and discussion in the academic world whichhas become an object of attention of researchaddressing teaching and teacher formation. Life history, initial and continuing formation, the meaning of teaching to the teacher, and also pedagogical practice are all contributing factors to teachers’ professional identity. The present study is a proposal developed in the research field of Educational Knowledge and Practice, and its main focus lies in university teaching. Higher education teaching in the context of a dance course, and the issues and challenges of constructing teachers’ professional identity are presented. Thus, my main questions were: what is the teaching path followed by newly hired dance teachers in the Federal University of Uberlândia? How is teaching identity developed in these new teachers’ professional socialization process? What kind of educational knowledge is (re)produced and mobilized by teachers when they join university teaching? In order to answer these questions, my objectives are: to analyze the teaching path of the newly hired dance teachers of the Federal University of Uberlândia; to investigate how their teaching identity is built within their professional socialization process; and identify the kinds of educational knowledge they (re)produce and mobilize as soon as they become university teachers. The present research comprises a qualitative data analysis from previous studies on the subject, having as starting point relevant bibliographic research, followed by an identification questionnaire and an interview conducted with the newly hired dance teachers. The construction of teaching identity is related to objective and subjective conditions involving a teaching job and how the teacher perceives this identity as constantly evolving. Hence I understand the importance of personal and institutional incentives to prepare studies which raise or problematize issues specific to this area, contributing to extend the debate over higher education professionals’ formation, in particular that of dance course teachers on national scope.

As estações ferroviárias do Triângulo Mineiro e Alto Paranaíba e suas interfaces: história e conservação

The implementation of the railway in Triângulo Mineiro and Alto Paranaíba helped to develop the area and connexion with other states: São Paulo, Goiás and Mato Grosso. The railway used to transport people and goods throughout many train stations in urban and rural areas and some major railroad complexes. There were many factors that led to the decline and abandonment of these properties: governmental policies which were in favour of road transportation and automotive industry, the replacement of the steam locomotive for electric and electric-diesel locomotives, changing part of the railway plan, removal of railways and loss of function of the buildings, extinction of passenger trains, which led the stations to lose its main purpose: people transport. 53% of the stations built inside the study area were demolished and most of them are in rural areas. There are several situations: stations on a precarious conservation state, most of them in the city s rural area, stations being used in urban and rural areas with new uses, stations working with cargo and goods transportation. The stations in Triângulo Mineiro and Alto Paranaíba area in Minas Gerais are the object of this dissertation, wherein the main interest lies on the stations that are in operation, 21 buildings, seeking to verify their conservation state, their agents and role in preserving the train memory. Maps, charts and tables were made for this collection s understanding, having visited the stations that are listed by the cultural heritage and the ones that are in operation with new functions. Field records were made allowing the understanding of these properties in operation. It is observed that only the buildings listing, despite ensuring the non-demolition, does not help on the use and preservation of these stations, because there are some buildings that have this protection level, but are abandoned and in disrepair. The use of these stations by a train company, operating with cargo and goods transportation do not also guarantee the buildings preservation, as they are not treated with any preservation interest, their maintenance are precarious. The using by these companies are various, however, only a few stations have internal spaces dedicated to the railroad memory. Most of the stations did not have preservation projects with architects and specialists participation and the major concern, during maintenance process, is on the building s external part. The stations conservation begins on the local government interest, that preserve these properties, most of them are in urban areas, the major challenge is on their using definition and occupancy, especially in the countryside, wherein the buildings uses must be sustainable, as regards the appreciation and management of this heritage.

Diversidade funcional em matas de galeria inundável e não inundável

As florestas ribeirinhas se dividem em matas ciliares e matas de galeria. As matas de galeria são importantes na manutenção dos recursos hídricos e da fauna a elas associada. Esses ambientes sofrem degradação e para a conservação e restauração são necessários estudos que entendam o funcionamento das espécies na comunidade. Os objetivos desse trabalho foram avaliar a variabilidade na área foliar específica em mata de galeria inundável do córrego do Glória (Uberlândia/MG) e mata de galeria não-inundável do ribeirão do Panga (Uberlândia/MG) e utilizar atributos reprodutivos como síndrome de polinização, síndrome de dispersão e sistema sexual, para comparação entre distintas áreas de mata de galeria inundável e também comparando com a mata de galeria não-inundável do Panga. Foram utilizados os dados florísticos já realizados nas matas de galeria não inundável do Panga (Uberlândia/MG), da mata de galeria inundável do Glória (Uberlândia/MG) e diversas outras matas de galeria inundável. A partir desses estudos foram calculados o IVC (Índice de Valor de Cobertura) e selecionadas as espécies. Para avaliar a variabilidade da área foliar específica foram utilizadas e as médias de AFE (área foliar específica) das espécies para comparação entre as duas áreas com o teste t de Student; já para analisar os padrões reprodutivos entre as matas de galeria inundável e compará-las com os padrões do Panga foram feitos testes de qui-quadrado. Os resultados do teste t mostraram que as médias das espécies da mata de galeria do Glória foram significativamente maiores do que as médias da mata de galeria do Panga. Protium heptaphyllum foi a única espécie co-ocorrente e também apresentou média significativamente maior na mata de galeria do Glória. As espécies vegetais com maiores AFE possuem uma maior captação de luz por unidade de biomassa investida, mas tendem a ter maior evaporação e perda de água. Por isso, a mata de galeria inundável, que não tem restrição hídrica para as espécies, pode apresentar maiores lâminas foliares. Com relação aos três atributos reprodutivos analisados, as áreas mostraram ser diferentes entre si e através de representação gráfica pode-se analisar que não houve padrões definidos entre as áreas, mas uma tendência a semelhanças entre várias áreas, principalmente em áreas próximas geograficamente, como as áreas de Uberlândia/MG. Quando comparados a padrões encontrados em outros estudos, as matas de galeria são semelhantes a outras áreas de floresta tropical, como alto índice de dioicia, que é relacionado a ambientes úmidos, maior porcentagem de dispersão zoocórica, especialmente por aves, e maior porcentagem de polinizadores generalistas, que são geralmente associados à dioicia.

Seleção de características para identificação de diferentes proporções de tipos de fibras musculares por meio da eletromiografia de superfície

Skeletal muscle consists of muscle fiber types that have different physiological and biochemical characteristics. Basically, the muscle fiber can be classified into type I and type II, presenting, among other features, contraction speed and sensitivity to fatigue different for each type of muscle fiber. These fibers coexist in the skeletal muscles and their relative proportions are modulated according to the muscle functionality and the stimulus that is submitted. To identify the different proportions of fiber types in the muscle composition, many studies use biopsy as standard procedure. As the surface electromyography (EMGs) allows to extract information about the recruitment of different motor units, this study is based on the assumption that it is possible to use the EMG to identify different proportions of fiber types in a muscle. The goal of this study was to identify the characteristics of the EMG signals which are able to distinguish, more precisely, different proportions of fiber types. Also was investigated the combination of characteristics using appropriate mathematical models. To achieve the proposed objective, simulated signals were developed with different proportions of motor units recruited and with different signal-to-noise ratios. Thirteen characteristics in function of time and the frequency were extracted from emulated signals. The results for each extracted feature of the signals were submitted to the clustering algorithm k-means to separate the different proportions of motor units recruited on the emulated signals. Mathematical techniques (confusion matrix and analysis of capability) were implemented to select the characteristics able to identify different proportions of muscle fiber types. As a result, the average frequency and median frequency were selected as able to distinguish, with more precision, the proportions of different muscle fiber types. Posteriorly, the features considered most able were analyzed in an associated way through principal component analysis. Were found two principal components of the signals emulated without noise (CP1 and CP2) and two principal components of the noisy signals (CP1 and CP2 ). The first principal components (CP1 and CP1 ) were identified as being able to distinguish different proportions of muscle fiber types. The selected characteristics (median frequency, mean frequency, CP1 and CP1 ) were used to analyze real EMGs signals, comparing sedentary people with physically active people who practice strength training (weight training). The results obtained with the different groups of volunteers show that the physically active people obtained higher values of mean frequency, median frequency and principal components compared with the sedentary people. Moreover, these values decreased with increasing power level for both groups, however, the decline was more accented for the group of physically active people. Based on these results, it is assumed that the volunteers of the physically active group have higher proportions of type II fibers than sedentary people. Finally, based on these results, we can conclude that the selected characteristics were able to distinguish different proportions of muscle fiber types, both for the emulated signals as to the real signals. These characteristics can be used in several studies, for example, to evaluate the progress of people with myopathy and neuromyopathy due to the physiotherapy, and also to analyze the development of athletes to improve their muscle capacity according to their sport. In both cases, the extraction of these characteristics from the surface electromyography signals provides a feedback to the physiotherapist and the coach physical, who can analyze the increase in the proportion of a given type of fiber, as desired in each case.

Corpo, força e potência: Nietzsche e Spinoza no pensamento de Deleuze

This dissertation aims at showing the importance of the Nietzsche s and Spinoza s philosophy in Deleuze thought, about body, force, and potency concepts. The search starts from Deleuze texts around two authors of his inspiration, reaching understand in the plan of immanence of the relationship between concepts and the way life as ethics and political affirmation. The first goal is the concept of rhizome; propose by Deleuze in what manner to walk the ways traced by philosophers and at the same time to create self ways. The second chapter examines the body in Nietzsche as force s relations. Find to show the genesis of the force in its determination as relative quantity strong or weak, and as absolute quality active or reactive; and for other side the genesis of the force from two poles of the will to power affirmation or negation, examining the consequences for life and thought. In the third chapter explained the definitions of body in Spinoza. The body, in Spinoza, defines itself complex relation of movement and repose, velocity and slowness and by it s to affect and be affecter s power. Find to show understanding the mediums for to amplify the power of to exist or the potency of to act, in what manner ethics of to live. The fourth chapter makes one parallel between the war and the thought in the constitution of socials body and collectives agenciamientos, for understand in the fifth chapter the body as war s machine of the thought, from the relationship between nomad way life and war s machine showed in Tractate of Nomadologia. Wait like this to show the importance of the ethics and political thought than affirm the existence in the world through active force from that body s power.

Determinação do estado fundamental de compostos antiferromagnéticos da série Tb(1-x)Y(x)RhIn(5): aproximação teórico experimental

We present the results of electrical resistivity, magnetic susceptibility, specific heat and x-ray absorption spectroscopy measurements in Tb1−xYxRhIn5 (x = 0.00, 0.15, 0.4.0, 0.50 e 0.70) single crystals. Tb1−xYxRhIn5 is an antiferromagnetic AFM compound with ordering temperature TN ≈ 46 K, the higher TN within the RRhIn5 serie (R : rare earth). We evaluate the physical properties evolution and the supression of the AFM state considering doping and Crystalline Electric Field (CEF) effects on magnetic exchange interaction between Tb3+ magnetic ions. CEF acts like a perturbation potential, breaking the (2J + 1) multiplet s degeneracy. Also, we studied linear-polarization-dependent soft x-ray absorption at Tb M4 and M5 edges to validate X-ray Absorption Spectroscopy as a complementary technique in determining the rare earth CEF ground state. Samples were grown by the indium excess flux and the experimental data (magnetic susceptibility and specific heat) were adjusted with a mean field model that takes account magnetic exchange interaction between first neighbors and CEF effects. XAS experiments were carried on Total Electron Yield mode at Laborat´onio Nacional de Luz S´ıncrotron, Campinas. We measured X-ray absorption at Tb M4,5 edges with incident polarized X-ray beam parallel and perpendicular to c-axis (E || c e E ⊥ c). The mean field model simulates the mean behavior of the whole system and, due to many independent parameters, gives a non unique CEF scheme. XAS is site- and elemental- specific technique and gained the scientific community s attention as complementary technique in determining CEF ground state in rare earth based compounds. In this work we wil discuss the non conclusive results of XAS technique in TbRhIn5 compounds.

Paulo Emílio Salles Gomes e a eficácia discursiva de sua intepretação histórica: reflexões sobre história e historiografia do cinema brasileiro

We intend with this research to contribute to the contemporary debate pertinent to the history of Brazilian cinema, its historiography and its writing procedures. Thereunto, we sustain the view that the historical interpretation composed by the essays Panorama do Cinema Brasileiro: 1896/1966 (1966) and Cinema: trajetória no subdesenvolvimento (1973) arranged by the critic and historian Paulo Emilio Salles Gomes, due to their epistemological postulates and narrative strategies, constitutes a version about the history of national cinema of expressive discursive efficacy.

Eficácia política de uma crítica: Paulo Emílio Salles Gomes e a constituição de uma teia interpretativa da história do cinema brasileiro

This work aims to contribute to theoretical and methodological analysis of writing the history of Brazilian cinema. The object of this study the trilogy of articles in Cinema: the trajectory of underdevelopment regimented, the critic and historian Paulo Emílio Salles Gomes, seeks to understand the process of setting up a web interpretative history of our film based on this work and how to rescue its historicity.

A influência das questões de gênero nos processos avaliativos escolares

This paper aims to discuss the influences of gender issues in formal and informal evaluation processes in order to identify situations that may lead to exclusion of boys and girls in our schools. Therefore, we rely on the authors as Freitas (2005, 2006, 2011), Sordi (2009), Villas Boas (2006), Fernandes (2006, 2008), (Carvalho (2001.2004, 2011), Blonde (1995, 2003), Scott (1995), Connell (1995), Navy (2009), Dal'igna (2004), among others. These authors help us understand that both gender issues as the evaluation questions in its formal and informal when analyzed, especially in light of school reality, are impregnated with socially constructed conceptions that are reflected in the school. The survey was conducted in two rooms of the 5th year of elementary school, and the genres of research were qualitative and quantitative. In the development of this study, the research followed those steps: School Rules analysis, grade maps, class journals; Mapping of records of the evaluation results of the 1st to 5th year of elementary school; Analysis of official government documents in education; development, implementation and analysis of questionnaires answered by the students and the teachers with issues about gender and evaluation; Mapping of the evaluation results of the students of two classes surveyed during 2012; Observation in the classroom; interview with the teachers of the surveyed groups. During the research we found that gender issues are not dealt with by the school and that this reinforces some exclusion processes that are linked to these questions. Studies also tell us that on the surveyed groups most of the children who have lower evaluative results are boys, which, in the evaluation of teachers, are considered undisciplined. Of the children with poor results, 50% are black. Some of these children who had low evaluative income have not completed the school year in that school. The study also reveals that on the observed groups, generally the girls have better results in formal assessments than boys, which are considered, by the teachers, more undisciplined and difficult to work with. The girls, on the other hand, are considered more docile and attentive than boys. The observations made by teachers concerning the behavior of boys and girls also reflect in the formal evaluative results, therefore the informal assessments, the value judgment of teachers in relation to the behavior of the students influence the results of formal assessments. In this sense, in order to seek ways to try to overcome the exclusion situations experienced in the evaluation process, we believe that the principles of popular education can be configured as an important parameter to begin discussions on gender and evaluation in schools.

Modelagem e análise dinâmica de um sistema de conversão de energia eólica dotado de gerador síncrono de imã permanente utilizando a plataforma ATP

Human development requires a broad balance between ecological, social and economic factors in order to ensure its own sustainability. In this sense, the search for new sources of energy generation, with low deployment and operation costs, which cause the least possible impact to the environment, has been the focus of attention of all society segments. To do so, the reduction in exploration of fossil fuels and the encouragement of using renewable energy resources for distributed generation have proved interesting alternatives to the expansion of the energy matrix of various countries in the world. In this sense, the wind energy has acquired an increasingly significant role, presenting increasing rates of power grid penetration and highlighting technological innovations such as the use of permanent magnet synchronous generators (PMSG). In Brazil, this fact has also been noted and, as a result, the impact of the inclusion of this source in the distribution and sub-transmission power grid has been a major concern of utilities and agents connected to Brazilian electrical sector. Thus, it is relevant the development of appropriate computational tools that allow detailed predictive studies about the dynamic behavior of wind farms, either operating with isolated load, either connected to the main grid, taking also into account the implementation of control strategies for active/reactive power generation and the keeping of adequate levels of voltage and frequency. This work fits in this context since it comprises mathematical and computational developments of a complete wind energy conversion system (WECS) endowed with PMSG using time domain techniques of Alternative Transients Program (ATP), which prides itself a recognized reputation by scientific and academic communities as well as by electricity professionals in Brazil and elsewhere. The modeling procedures performed allowed the elaboration of blocks representing each of the elements of a real WECS, comprising the primary source (the wind), the wind turbine, the PMSG, the frequency converter, the step up transformer, the load composition and the power grid equivalent. Special attention is also given to the implementation of wind turbine control techniques, mainly the pitch control responsible for keeping the generator under the maximum power operation point, and the vector theory that aims at adjusting the active/reactive power flow between the wind turbine and the power grid. Several simulations are performed to investigate the dynamic behavior of the wind farm when subjected to different operating conditions and/or on the occurrence of wind intensity variations. The results have shown the effectiveness of both mathematical and computational modeling developed for the wind turbine and the associated controls.

Estudo dos harmônicos entre diferentes sistemas de excitação de máquinas síncronas

Dissertação (Mestrado)

Uma proposta para o ensino das estações do ano com base em um referencial topocêntrico

Studies carried out in several countries have confirmed the students’ difficulty in explaining the causes of the seasons of the year, and most of times their learning takes place incorrectly. The seasons of the year have been generally treated in didactic books apart from people´s routine, based on the heliocentric system, what demands abstraction to understand the phenomenon. Before this difficulty, it is necessary to think about a teaching proposal which allows the students to realize the environmental characteristics and its changes over time, as well as the seasons themselves. Thus, our goal was to work from the perspective of the observer on the terrestrial surface, therefore using the topocentric system. For that, we constructed a didactic sequence, grounded in Ausubel´s meaningful learning theory (2003) and in Moreira´s critical meaningful learning theory (2010), which was applied to students in 9th grade of elementary school and in 2th grade of high school at Escola Estadual Jerônimo Arantes, in Uberlândia, Minas Gerais, owing to their previous knowledge and alternative conceptions, which were collected via interviews. Afterwards, to evaluate the applied methodology, we made new interviews, by which we realized improvement in learning in relation to the characteristics of the seasons based on Sun´s apparent path, which we attribute to reference the change of observation and the means to obtain data on the volume of rainfall and average temperature in the city throughout the year. On the other hand, there are points that were not highlighted in learning, such as the link between winter and rainy season and the causes of the seasons, points left to be discussed in future investigations.

Degradação de paracetamol empregando tecnologia oxidativa avançada baseada em fotocatálise heterogênea usando irradiação artificial e solar

In this work, the oxidation and mineralization of paracetamol, based in an advanced oxidative process promoted by heterogeneous photocatalysis, was evaluated. The action of two photocatalysts (titanium dioxide, and a composite based on the association between titanium dioxide and zinc phthalocyanine dye) was studied. First of all, experiments in laboratory scale were performed using as radiation font a 400 W high pressure mercury lamp. The mineralization of paracetamol, promoted by both photocatalysts, was evaluated working with 4L of solution containing 10 mg L-1 of paracetamol and 100 mg L-1 of photocatalyst. To find the best experimental conditions, the influence of hydrogen peroxide concentration and pH was evaluated for the reactions. The best results for the reactions in laboratory scale was obtained using 33,00 mg L-1 of hydrogen peroxide in natural pH (6,80). Under these conditions, 100% oxidation was reached in just 40 minutes of reaction using TiO2 P25, while the mineralization was 78%. Using the composite, the mineralization was 63% in 2 hours of reaction and a oxidation of almost 100% was reached after 60 minutes. A CPC reactor (compound parabolic concentrator) was employed in the expanded work scale, using the sun as irradiation source. In this case the experiments were performed using 50 L of aqueous solution containing 10 mg L-1 of paracetamol and 100 mg L-1 of photocatalyst. The assays were done at pH 3,00 and natural pH (6,80). The used concentration of hydrogen peroxide was 33,00 mg L-1, adopted after laboratory scale studies. The reaction at pH 3,00 shows to be more advantageous, since under natural pH (6,80), the use of deionized water was necessary to prepare the solutions, probably because the deleterious action of carbonate ions, known hydroxyl radical scavengers. Using solar irradiation, the reaction mediated by the composite was more efficient when compared with the assays under laboratory scale since the composite presents the advantage of promoting a better use of visible radiation. Under these conditions, the mineralization increased from 40% to 56% under pH 3,00. At natural pH the oxidation occurred more slowly and the mineralization decreased from 56% to 50%. Thus, the use of pH 3,00 will be more interesting in real scale applications, even if it is necessary the pH correction before the discard of the treated effluent to the environment.

Reconstrução e reconhecimento de imagens binárias utilizando o algoritmo Máquina de Boltzmann

The objective of this work is to use algorithms known as Boltzmann Machine to rebuild and classify patterns as images. This algorithm has a similar structure to that of an Artificial Neural Network but network nodes have stochastic and probabilistic decisions. This work presents the theoretical framework of the main Artificial Neural Networks, General Boltzmann Machine algorithm and a variation of this algorithm known as Restricted Boltzmann Machine. Computer simulations are performed comparing algorithms Artificial Neural Network Backpropagation with these algorithms Boltzmann General Machine and Machine Restricted Boltzmann. Through computer simulations are analyzed executions times of the different described algorithms and bit hit percentage of trained patterns that are later reconstructed. Finally, they used binary images with and without noise in training Restricted Boltzmann Machine algorithm, these images are reconstructed and classified according to the bit hit percentage in the reconstruction of the images. The Boltzmann machine algorithms were able to classify patterns trained and showed excellent results in the reconstruction of the standards code faster runtime and thus can be used in applications such as image recognition.