Análise computacional do desempenho de estratégia para o religamento controlado de linhas de transmissão

The search for mitigation solutions, with respect to the effects of overvoltages linked to the energization and reclosing maneuvers of transmission lines include a challenging subject with strong impact on the insulation coordination of electrical systems. Although the recognition of classical and commercial proposals to mitigate these phenomena, other possibilities are certainly still worthwhile highlighting and investigations. In this context, the present work is grounded in the exposure of the physical and mathematical foundations of a strategy based on controlled switchings, whose moments to the line reclosing are pre-programmed. The computational evaluation of the effectiveness of the methodology is made using the ATP simulator, which are studies in a typical electrical system subjected to the action of short-circuits fallowed by shutdowns and subsequent reclosing, under the action of technology here focused and lack thereof.

Análise do perfil imunológico e citohistológico durante a transmissão vertical de Trypanosoma cruzi em diferentes estágios da infecção experimental

Trypanosma cruzi is the causative agent of Chagas disease. This trypanosomiasis has become a global public health problem due to migration of Latin Americans to non-endemic countries. In Latin America with the succesful implementation of control domiciliated vector infestation and blood transfusion, the importance of congenital transmission has recently increased. Considering the tight regulation of immune system during gestation, we aimed to investigate the changes in the immune system caused by T.cruzi infection in the gestation outcome. T cruzi G and Y strain were used to infect female BALB/c mice before or after mating with non-infected male mice. The presence of vaginal plug was used as indicative of mating. Females were euthanized 8 days after confirmation of vaginal plug. We used three female control groups, only infected, only infected and non-infected and non-pregnant females. Two groups were infected before mating and other two were infected 4 days after confirmation of vaginal plug. The uterus and spleen were collected to immunochemistry, qPCR, immunofluorescence and cytokine analysis. Our results showed that despite the MMP’s identification being similarly among groups, T.cruzi higher virulent strain can impaire gestation outcome prior mating; the infection also increased cytokines like IFN-γ, IL-1β and IL-4; and leucocytes in uterine environment was altered, responding locally to systemic changes caused by T.cruzi infection. In conclusion this work suggests that T.cruzi infection can impaire gestation outcome and local response to sistemic infection was able to control the infection allowing pregnancy development in some conditions.