Efeito do exercício físico na estabilidade de membrana de eritrócitos

CHAPTER II - This study evaluated the effects of two different types of acute aerobic exercise on the osmotic stability of human erythrocyte membrane and on different hematological and biochemical variables that are associated with this membrane property. The study population consisted of 20 healthy and active men. Participants performed single sessions of two types of exercise. The first session consisted of 60 min of moderate-intensity continuous exercise (MICE). The second session, executed a week later, consisted of high-intensity interval exercise (HIIE) until exhaustion. The osmotic stability of the erythrocyte membrane was represented by the inverse of the salt concentration (1/H50) at the midpoint of the sigmoidal curve of dependence between the absorbance of hemoglobin and the NaCl concentration. The values of 1/H50 changed from 2.29 ± 0.1 to 2.33 ± 0.09 after MICE and from 2.30 ± 0.08 to 2.23 ± 0.12 after HIIE. In MICE has occurred an increase in the mean corpuscular volume, probably due to in vivo lysis of older erythrocytes, with preservation of cells that were larger and more resistant to in vitro lysis. The study showed that a single bout of acute exercise affected the erythrocyte osmotic stability, which increased after MICE and decreased after HIIE.

Tradução e adaptação transcultural do domínio função física do Patient-Reported Outcomes Measurement Information System – PROMIS® - versão para a língua portuguesa

In 2004, the National Institutes of Health made available the Patient-Reported Outcomes Measurement Information System – PROMIS®, which is constituted of innovative item banks for health assessment. It is based on classical, reliable Patient-Reported Outcomes (PROs) and includes advanced statistical methods, such as Item Response Theory and Computerized Adaptive Test. One of PROMIS® Domain Frameworks is the Physical Function, whose item bank need to be translated and culturally adapted so it can be used in Portuguese speaking countries. This work aimed to translate and culturally adapt the PROMIS® Physical Function item bank into Portuguese. FACIT (Functional Assessment of Chronic Illness Therapy) translation methodology, which is constituted of eight stages for translation and cultural adaptation, was used. Fifty subjects above the age of 18 years participated in the pre-test (seventh stage). The questionnaire was answered by the participants (self-reported questionnaires) by using think aloud protocol, and cognitive and retrospective interviews. In FACIT methodology, adaptations can be done since the beginning of the translation and cultural adaption process, ensuring semantic, conceptual, cultural, and operational equivalences of the Physical Function Domain. During the pre-test, 24% of the subjects had difficulties understanding the items, 22% of the subjects suggested changes to improve understanding. The terms and concepts of the items were totally understood (100%) in 87% of the items. Only four items had less than 80% of understanding; for this reason, it was necessary to chance them so they could have correspondence with the original item and be understood by the subjects, after retesting. The process of translation and cultural adaptation of the PROMIS® Physical Function item bank into Portuguese was successful. This version of the assessment tool must have its psychometric properties validated before being made available for clinical use.

As vogais médias tônicas: um estudo contrastivo da metafonia com base em corpus

This research analyzes the average previous stressed vowels [ε] and [e] and later [ɔ] and [o] in nominal and verbal forms in the 1st person singular and 3rd person singular and plural in the present tense, specifically the umlaut process of mid vowels /e/ and /o/, which assimilate in /ε/ and /ᴐ/ in stressed position. The general objective of this research is to describe and quantify the occurrence of umlaut and subsequently analyze in which words there is regularity or not. As specific objectives we have: i) to compile and to label an oral, spontaneous, synchronic and regional corpus, from radio programs produced in the city of Ituiutaba, Minas Gerais; ii) to describe the characteristics of the corpus to be compiled; iii) to investigate the alternating timbre of mid vowels in stressed position; iv) to identify instances of nominal and verbal umlaut of the middle vowels in stressed position; v) to describe the identified cases of nominal and verbal umlaut; vi) to analyze the probable causes for the variation of the middle vowels. To perform the proposed analysis, we have adopted as a theoretical-methodological basis multi-representational models: Phonology of Use (BYBEE, 2001) and Exemplar Theory (PIERREHUMBERT, 2001) combined with the precepts of Corpus Linguistics (BEBER SARDINHA, 2004). The corpus consisted of 16 radio programs – eight political and eight religious – from the city of Ituiutaba-MG, with recordings of about 20 to 40 minutes. We note, by means of the results generated by WordSmith Tools® software, version 6.0 (SCOTT, 2012), that the analyzed forms show little variation, which shows that the umlaut is a process already lexicalized in participants of the radio programs analyzed. We conclude that the results converge with the proposal of the Phonology of Use (BYBEE, 2001; PHILLIPS, 1984) that less frequent words that have no phonetic environment conducive to change, are changed first.