6 resultados para Protein Array Analysis -- methods

em Bulgarian Digital Mathematics Library at IMI-BAS


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Report published in the Proceedings of the National Conference on "Education and Research in the Information Society", Plovdiv, May, 2016

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The article proposes the model of management of information about program flow analysis for conducting computer experiments with program transformations. It considers the architecture and context of the flow analysis subsystem within the framework of Specialized Knowledge Bank on Program Transformations and describes the language for presenting flow analysis methods in the knowledge bank.

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Computing the similarity between two protein structures is a crucial task in molecular biology, and has been extensively investigated. Many protein structure comparison methods can be modeled as maximum weighted clique problems in specific k-partite graphs, referred here as alignment graphs. In this paper we present both a new integer programming formulation for solving such clique problems and a dedicated branch and bound algorithm for solving the maximum cardinality clique problem. Both approaches have been integrated in VAST, a software for aligning protein 3D structures largely used in the National Center for Biotechnology Information, an original clique solver which uses the well known Bron and Kerbosch algorithm (BK). Our computational results on real protein alignment instances show that our branch and bound algorithm is up to 116 times faster than BK.

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2000 Mathematics Subject Classi cation: Primary 90C31. Secondary 62C12, 62P05, 93C41.

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The reasons of a restricted applicability of the models of decision making in social and economic systems. 3 basic principles of growth of their adequacy are proposed: "localization" of solutions, direct account of influencing of the individual on process of decision making ("subjectivity of objectivity") and reduction of influencing of the individual psychosomatic characteristics of the subject (" objectivity of subjectivity ") are offered. The principles are illustrated on mathematical models of decision making in ecologically- economic and social systems.

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Владимир Димитров - Целта на настоящия доклад е формалната спецификация на релационния модел на данни. Тази спецификация след това може да бъде разширена към Обектно-релационния модел на данни и към Потоците от данни.