In memoriam: Dimitar Shishkov

Bulgarian and world computer science lost a prominent colleague: Dimitar Petrov Shishkov 22th January 1939, Varna – 8th March 2004, Sofia D. Shishkov graduated mathematics at Sofia University in 1962. In the last year of his studies he started a specialization as a programmer at the Joint Institute of Nuclear Research – Dubna which lasted three years. Then he worked at the Institute of Mathematics for two years. In 1966 D. Shishkov together with a group of experts transferred to the newly created Central Laboratory for Information Technologies. In 1976 he defended his PhD dissertation. He has been an associate professor in computer science at Sofia University since 1985 and a professor in computer science since 2000. His scientific interests and results were in the fields of computer architectures, computational linguistics, artificial intelligence, numerical methods, data structures, etc. He was remarkable with his teaching activities. D. Shishkov was the creator of high-quality software for the first Bulgarian electronic calculator “ELKA” – one of the first calculators in the world as well as for the series of next calculators and for specialized minicomputers. He was the initiator of the international project “Computerization of the natural languages”. He was a member of a range of international scientific organizations. Among his numerous activities was the organization of the I-st Programming competition in 1979. D. Shishkov was the initiator of sport dancing in Bulgaria (1967) and founder of the first sport-dancing high school education in the world. D. Shishkov was a highly accomplished person with a diversity of interests, with a developed social responsibility and accuracy in his work. In 1996 D. Shishkov was awarded with the International Prize ITHEA for outstanding achievements in the field of Information Theories and Applications. We are grateful to D. Shishkov for the chance to work together with him for establishment and development of IJ ITA.

Em Algorithm for MLE of a Probit Model for Multiple Ordinal Outcomes

The correlated probit model is frequently used for multiple ordered data since it allows to incorporate seamlessly different correlation structures. The estimation of the probit model parameters based on direct maximization of the limited information maximum likelihood is a numerically intensive procedure. We propose an extension of the EM algorithm for obtaining maximum likelihood estimates for a correlated probit model for multiple ordinal outcomes. The algorithm is implemented in the free software environment for statistical computing and graphics R. We present two simulation studies to examine the performance of the developed algorithm. We apply the model to data on 121 women with cervical or endometrial cancer. Patients developed normal tissue reactions as a result of post-operative external beam pelvic radiotherapy. In this work we focused on modeling the effects of a genetic factor on early skin and early urogenital tissue reactions and on assessing the strength of association between the two types of reactions. We established that there was an association between skin reactions and polymorphism XRCC3 codon 241 (C>T) (rs861539) and that skin and urogenital reactions were positively correlated. ACM Computing Classification System (1998): G.3.