7 resultados para Gaussian quadrature formulas.

em Bulgarian Digital Mathematics Library at IMI-BAS


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MSC 2010: 33C47, 42C05, 41A55, 65D30, 65D32

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* This work was financially supported by the Russian Foundation for Basic Research, project no. 04-01-00858a.

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Mathematics Subject Classification: 42A38, 42C40, 33D15, 33D60

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The quantitative analysis of receptor-mediated effect is based on experimental concentration-response data in which the independent variable, the concentration of a receptor ligand, is linked with a dependent variable, the biological response. The steps between the drug–receptor interaction and the subsequent biological effect are to some extent unknown. The shape of the fitting curve of the experimental data may give some in-sights into the nature of the concentration–receptor–response (C-R-R) mechanism. It can be evaluated by non-linear regression analysis of the experimental data points of the independent and dependent variables, which could be considered as a history of the interaction between the drug and receptors. However, this information is not enough to evaluate such important parameters of the mechanism as the dissociation constant (affinity) and efficacy. There are two ways to provide more detailed information about the C-R-R mechanism: (i) an experimental way for obtaining data with new or

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2010 Mathematics Subject Classification: Primary 65D30, 32A35, Secondary 41A55.

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2000 Mathematics Subject Classification: 60G15, 60G60; secondary 31B15, 31B25, 60H15

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MSC 2010: 33C15, 33C05, 33C45, 65R10, 20C40