Regional variability in visual field sensitivity during hypercapnia

PURPOSE: Previous investigations have demonstrated a relative vascular autoregulatory inefficiency of the inferior compared to the superior retina in healthy subjects breathing increased CO2. The purpose of this study was to determine whether the superior and inferior visual field sensitivities of healthy eyes are similarly affected during mild hypercapnia. DESIGN: Experimental study. METHODS: Visual field analysis (Humphrey Field Analyser; SITA standard 24-2 program) was carried out on one randomly selected eye of 22 subjects (mean age, 27.7 ± 5 years) during normal room air breathing and isoxic hypercapnia. The Student paired t-tests were used to compare the visual field indices mean deviation (MD) and pattern standard deviation (PSD) for each breathing condition. A secondary, sectoral analysis of mean pointwise sensitivity was performed for each condition. In each case a P value of <.01 was considered statistically significant (Bonferroni corrected). RESULTS: Visual field MD was -0.23 ± 0.95dB during room air breathing and -0.49 ± 1.04dB during hypercapnia (P = .034). Sectoral pointwise mean sensitivity deteriorated by 0.46dB (P = .006) in the upper visual hemifield during hypercapnia, whereas no significant difference was observed for the lower hemifield (P = .331). CONCLUSIONS: The upper visual hemifield exhibited a significantly greater degree of deterioration in pointwise visual field mean sensitivity compared to the lower hemifield during hypercapnic conditions. This suggests that the upper visual hemifield and hence inferior retina is more susceptible to insult during hypercapnia than the superior retina in healthy individuals. A regional susceptibility of inferior retinal function to altered vascular or metabolic effects may account for the earlier and more frequent inferior nerve fibre damage associated with glaucomatous optic neuropathy. © 2003 by Elsevier Science Inc. All rights reserved.

Oxygenation for fish farms

This thesis provides a detailed study of methods for dissolving oxygen in water to reduce water requirements for fish farming. The principal sources of oxygen are air or pure oxygen gas. Aeration methods have the distinct advantage of the universal availability of air. However, the effectiveness of such methods is diminished by the presence of nitrogen in the air and, in general, the maintenance of dissolved oxygen levels above 70% saturation is likely to result in excessive power requirements. Pure oxygen has five times the solubility of oxygen in air and it is possible, therefore to achieve much higher transfer rates. However, oxygen is expensive and its economic use is essential: it is important, therefore, to dissolve a high proportion of the oxygen. Four distinct oxygenation systems were evaluated by the author. A detailed analysis of a column oxygenator is given first. The column was designed so that the oxygen bubbles generated are trapped within the column until dissolved. In seawater, much smaller bubbles are formed and this led to the development of a jet oxygenator which disperses gas rubbles within the rearing tank. Both the above systems were designed primarily for oxygenating recycled tank water. For oxygenating a primary water source, a U -tube device was evaluated. Lastly, the possibility of supporting fish stocks without any external power source, other than a pressured supply of oxygen from a liquid oxygen store, was considered. Experience of running commercial-scale oxygenation systems in high-intensity fish farms has made it possible to estimate operating costs of both aeration and oxygenation systems. The significance of these costs is discussed.