Tracing requirements for adaptive systems using claims

The complexity of environments faced by dynamically adaptive systems (DAS) means that the RE process will often be iterative with analysts revisiting the system specifications based on new environmental understanding product of experiences with experimental deployments, or even after final deployments. An ability to trace backwards to an identified environmental assumption, and to trace forwards to find the areas of a DAS's specification that are affected by changes in environmental understanding aids in supporting this necessarily iterative RE process. This paper demonstrates how claims can be used as markers for areas of uncertainty in a DAS specification. The paper demonstrates backward tracing using claims to identify faulty environmental understanding, and forward tracing to allow generation of new behaviour in the form of policy adaptations and models for transitioning the running system. © 2011 ACM.

The relationship between high-sensitivity CRP and polyclonal Free Light Chains as markers of inflammation in chronic disease

Introduction: Serum concentrations of polyclonal free light chains (FLC) represent the activity of the adaptive immune system. This study assessed the relationship between polyclonal FLC and the established marker of innate immunity, C-reactive protein (CRP), in chronic and acute disease. Methods: We utilized four cross-sectional chronic disease patient cohorts: chronic kidney disease (CKD), diabetes, vasculitis and kidney transplantation; and a longitudinal intensive care case series to assess the kinetics of production in acute disease. Results: There was a weak association between polyclonal FLC and high-sensitivity CRP (hs-CRP) in the study cohorts. A longitudinal assessment in acute disease showed a gradual increase in FLC concentrations over time, often when CRP levels were falling, demonstrating clear differences in the response kinetics of CRP and FLC in this setting. Conclusion: Polyclonal FLC and hs-CRP provide independent information as to inflammatory status. Prospective studies are now required to assess the utility of hs-CRP and polyclonal FLC in combination for risk stratification in disease populations. © 2013 John Wiley & Sons Ltd.