UncertML: an XML schema for exchanging uncertainty

Authors from Burrough (1992) to Heuvelink et al. (2007) have highlighted the importance of GIS frameworks which can handle incomplete knowledge in data inputs, in decision rules and in the geometries and attributes modelled. It is particularly important for this uncertainty to be characterised and quantified when GI data is used for spatial decision making. Despite a substantial and valuable literature on means of representing and encoding uncertainty and its propagation in GI (e.g.,Hunter and Goodchild 1993; Duckham et al. 2001; Couclelis 2003), no framework yet exists to describe and communicate uncertainty in an interoperable way. This limits the usability of Internet resources of geospatial data, which are ever-increasing, based on specifications that provide frameworks for the ‘GeoWeb’ (Botts and Robin 2007; Cox 2006). In this paper we present UncertML, an XML schema which provides a framework for describing uncertainty as it propagates through many applications, including online risk management chains. This uncertainty description ranges from simple summary statistics (e.g., mean and variance) to complex representations such as parametric, multivariate distributions at each point of a regular grid. The philosophy adopted in UncertML is that all data values are inherently uncertain, (i.e., they are random variables, rather than values with defined quality metadata).

PPD v1.0 - an integrated, web-accessible database of experimentally determined protein pKa values

The Protein pKa Database (PPD) v1.0 provides a compendium of protein residue-specific ionization equilibria (pKa values), as collated from the primary literature, in the form of a web-accessible postgreSQL relational database. Ionizable residues play key roles in the molecular mechanisms that underlie many biological phenomena, including protein folding and enzyme catalysis. The PPD serves as a general protein pKa archive and as a source of data that allows for the development and improvement of pKa prediction systems. The database is accessed through an HTML interface, which offers two fast, efficient search methods: an amino acid-based query and a Basic Local Alignment Search Tool search. Entries also give details of experimental techniques and links to other key databases, such as National Center for Biotechnology Information and the Protein Data Bank, providing the user with considerable background information.

Modulating membership grades to gain consensus for fuzzy set uncertainty values in a clinical decision support system

This paper deals with a very important issue in any knowledge engineering discipline: the accurate representation and modelling of real life data and its processing by human experts. The work is applied to the GRiST Mental Health Risk Screening Tool for assessing risks associated with mental-health problems. The complexity of risk data and the wide variations in clinicians' expert opinions make it difficult to elicit representations of uncertainty that are an accurate and meaningful consensus. It requires integrating each expert's estimation of a continuous distribution of uncertainty across a range of values. This paper describes an algorithm that generates a consensual distribution at the same time as measuring the consistency of inputs. Hence it provides a measure of the confidence in the particular data item's risk contribution at the input stage and can help give an indication of the quality of subsequent risk predictions. © 2010 IEEE.