High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix

Conventional differential scanning calorimetry (DSC) techniques are commonly used to quantify the solubility of drugs within polymeric-controlled delivery systems. However, the nature of the DSC experiment, and in particular the relatively slow heating rates employed, limit its use to the measurement of drug solubility at the drug's melting temperature. Here, we describe the application of hyper-DSC (HDSC), a variant of DSC involving extremely rapid heating rates, to the calculation of the solubility of a model drug, metronidazole, in silicone elastomer, and demonstrate that the faster heating rates permit the solubility to be calculated under non-equilibrium conditions such that the solubility better approximates that at the temperature of use. At a heating rate of 400°C/min (HDSC), metronidazole solubility was calculated to be 2.16 mg/g compared with 6.16 mg/g at 20°C/min. © 2005 Elsevier B.V. All rights reserved.

Tradition versus technology:careers fairs in the 21st Century

The traditional methods of graduate recruitment do not adequately meet the needs of the changing profile of students and graduates. As industry becomes internationalized, the needs of employers are also changing. Graduate recruitment is in response to short term needs and varying levels of experience are required. A case study method was used in Dublin Institute of Technology to evaluate effectiveness of a virtual careers fair in providing greater access to job opportunities for students and graduates. Access by employers to potential employees was also measured. Findings showed that while access improved, other issues requiring attention emerged.

Think small. The construction of imagined tradition in German "Land"-magazines

This article is the first linguistic analysis of a new category of lifestyle magazines in the German speaking countries, based on methods of corpus linguistics and multimodal discourse analysis. Since the launch of the magazine LandLust in Germany in 2005, more than twenty publications of so called "land magazines" have appeared on the market, attracting millions of readers. Our research analyses land magazines as discursive events. We examine the specific combination of discourses land magazines are serving or creating by looking at the semiotic practices – writing and images – they manifest themselves by. Our results show that the magazine under scrutiny does not simply provide new forms of escapism but also positions itself politically in subtle ways as part of the traditional-conservative spectrum by reacting to metalinguistic discourses such as purism and feminist criticism.