A new stylometric technique for the invesigation of the true authorship of the early works of Shakespeare

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT

The optimisation of legacy water treatment works to produce a more consistent final water quality

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT

Paediatric 'care closer to home':stake-holder views and barriers to implementation

In this study we explore the views of NHS stakeholders on providing paediatric ‘care closer to home’ (CCTH), in community-based outpatient clinics delivered by consultants. Design: Semi-structured interviews and thematic framework analysis. Setting: UK specialist children's hospital and surrounding primary care trusts. Participants: 37 NHS stakeholders including healthcare professionals, managers, commissioners and executive team members. Results: Participants acknowledged that outreach clinics would involve a change in traditional ways of working and that the physical setting of the clinic would influence aspects of professional practice. Different models of CCTH were discussed, as were alternatives for improving access to specialist care. Participants supported CCTH as a good principle for paediatric outpatient services; however the challenges of setting up and maintaining community clinics meant they questioned how far it could be achieved in practice. Conclusions: The place of service delivery is both an issue of physical location and professional identity. Policy initiatives which ignore assumptions about place, power and identity are likely to meet with limited success.

Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease

Poor maternal nutrition during pregnancy can alter postnatal phenotype and increase susceptibility to adult cardiovascular and metabolic diseases. However, underlying mechanisms are largely unknown. Here, we show that maternal low protein diet (LPD), fed exclusively during mouse preimplantation development, leads to offspring with increased weight from birth, sustained hypertension, and abnormal anxiety-related behavior, especially in females. These adverse outcomes were interrelated with increased perinatal weight being predictive of later adult overweight and hypertension. Embryo transfer experiments revealed that the increase in perinatal weight was induced within blastocysts responding to preimplantation LPD, independent of subsequent maternal environment during later pregnancy. We further identified the embryo-derived visceral yolk sac endoderm (VYSE) as one mediator of this response. VYSE contributes to fetal growth through endocytosis of maternal proteins, mainly via the multiligand megalin (LRP2) receptor and supply of liberated amino acids. Thus, LPD maintained throughout gestation stimulated VYSE nutrient transport capacity and megalin expression in late pregnancy, with enhanced megalin expression evident even when LPD was limited to the preimplantation period. Our results demonstrate that in a nutrient-restricted environment, the preimplantation embryo activates physiological mechanisms of developmental plasticity to stablize conceptus growth and enhance postnatal fitness. However, activation of such responses may also lead to adult excess growth and cardiovascular and behavioral diseases. © 2008 by the Society for the Study of Reproduction, Inc.

„Fern im dänischen Norden ein Bruder”:Thomas Mann und Herman Bang. Eine literarische Spurensuche

This study for the first time demonstrates and analyses the full extent of Danish impressionist writer Herman Bang’s influence on one of Germany’s major authors, Thomas Mann. Mann was an avid reader of Bang’s works and he regarded the Scandinavian writer as a kindred spirit, a “brother up north”, who “taught [him] much”. It has previously been accepted that Bang was an inspiration for Mann in his formative years. However, as this study conclusively shows, references to Bang’s works occur throughout Mann’s writings, from the early novellas to the late novels. The book argues that Mann was not only impressed by Bang’s highly individual style of impressionist writing but that his fascination for Bang’s works was to a large extent based on this author’s recurrent depiction of decadence, his handling of artistic motifs and his treatment of erotic themes. Bang’s topical focus on the problematically isolated lives of artists and aristocrats as well as his insights on the destructive nature of love and sexuality – particularly of homoerotic desire – were surprisingly similar to Mann’s own views on these topics and yet provoked him to produce heavily referenced counter versions of Bang’s works. This phenomenon is explored in the context of Mann’s struggle with his own homosexuality and the attraction that death and decadence exerted over him. Most of Mann’s writings are in that way indebted to Bang. In addition, Mann’s frequent use of homoerotic subtexts and his depiction of female characters were noticeably influenced by Bang’s literary techniques. All these different, yet closely interlinked, aspects of Mann’s creative appropriation of Bang’s works are analysed and discussed in this study. To conclude, Mann’s references to Bang’s works are schematised and an attempt is made to characterise Mann’s intertextual practice in general in the context of his famous use of irony.