Fetal growth restriction results in remodeled and less efficient hearts in children

Background— Fetal growth restriction (FGR) affects 5% to 10% of newborns and is associated with increased cardiovascular mortality in adulthood. The most commonly accepted hypothesis is that fetal metabolic programming leads secondarily to diseases associated with cardiovascular disease, such as obesity, diabetes mellitus, and hypertension. Our main objective was to evaluate the alternative hypothesis that FGR induces primary cardiac changes that persist into childhood. Methods and Results— Within a cohort of fetuses with growth restriction identified in fetal life and followed up into childhood, we randomly selected 80 subjects with FGR and compared them with 120 normally grown fetuses, matched for gender, birth date, and gestational age at birth. Cardiovascular assessment was performed in childhood (mean age of 5 years). Compared with control subjects, children with FGR had a different cardiac shape, with increased transversal diameters and more globular cardiac ventricles. Although left ejection fraction was similar among the study groups, stroke volume was reduced significantly, which was compensated for by an increased heart rate to maintain output in severe FGR. This was associated with subclinical longitudinal systolic dysfunction (decreased myocardial peak velocities) and diastolic changes (increased E/E' ratio and E deceleration time). Children with FGR also had higher blood pressure and increased intima-media thickness. For all parameters evaluated, there was a linear increase with the severity of growth restriction. Conclusions— These findings suggest that FGR induces primary cardiac and vascular changes that could explain the increased predisposition to cardiovascular disease in adult life. If these results are confirmed, the impact of strategies with beneficial effects on cardiac remodeling should be explored in children with FGR.

Time-spatial drift of decelerating electromagnetic pulses

A time dependent electromagnetic pulse generated by a current running laterally to the direction of the pulse propagation is considered in paraxial approximation. It is shown that the pulse envelope moves in the time-spatial coordinates on the surface of a parabolic cylinder for the Airy pulse and a hyperbolic cylinder for the Gaussian. These pulses propagate in time with deceleration along the dominant propagation direction and drift uniformly in the lateral direction. The Airy pulse stops at infinity while the asymptotic velocity of the Gaussian is nonzero. © 2013 Optical Society of America.

Reflection of a spatial-temporal airy pulse from a layer

The interaction of an Airy pulse with a dielectric layer is investigated theoretically. Approximate analytical expressions for reflected and transmitted waves are derived in the form of Taylor series. These series consist of shifted Airy pulses which are decelerated in time and space and deceleration becomes stronger with a number of a term of series. © 2012 IEEE.

Time-varying airy pulses

Pulses in the form of the Airy function as solutions to an equation similar to the Schrodinger equation but with opposite roles of the time and space variables are derived. The pulses are generated by an Airy time varying field at a source point and propagate in vacuum preserving their shape and magnitude. The pulse motion is decelerating according to a quadratic law. Its velocity changes from infinity at the source point to zero in infinity. These one dimensional results are extended to the 3D+time case for a similar Airy-Bessel pulse with the same behaviour, the non-diffractive preservation and the deceleration. This pulse is excited by the field at a plane aperture perpendicular to the direction of the pulse propagation. © 2011 IEEE.

Decelerating Airy pulses

It is shown that an electromagnetic wave equation in time domain is reduced in paraxial approximation to an equation similar to the Schrodinger equation but in which the time and space variables play opposite roles. This equation has solutions in form of time-varying pulses with the Airy function as an envelope. The pulses are generated by a source point with an Airy time varying field and propagate in vacuum preserving their shape and magnitude. The motion is according to a quadratic law with the velocity changing from infinity at the source point to zero in infinity. These one-dimensional results are extended to the 3D+time case when a similar Airy-Bessel pulse is excited by the field at a plane aperture. The same behaviour of the pulses, the non-diffractive preservation and their deceleration, is found. © 2011 IEEE.