Une histoire du sens:la sémantique linguistique depuis Bréal

Il y a plus d'un siècle, Michel Bréal institua l'analyse du sens dans le langage. À partir de là, le développement de la sémantique repose sur des paradigmes, qui constituent de véritables métaphores de la nature générale du langage. Cet ouvrage montre que, hors des modèles logiques, la sémantique s'est historiquement développée à travers quatre paradigmes. Le sens linguistique relève de la vie mentale des individus pour le paradigme psychologiste qui réunit Bréal, Brunot, Damourette et Pichon, Guillaume et Bally. La nature incertaine de cette vie mentale porte le structuralisme de Saussure, Greimas, Rastier et Wierzbicka à envisager le sens comme dérivant de l'équilibre des oppositions internes à la langue. Les déterminismes de cette organisation sont associés aux conditions de sa mise en oeuvre pour le paradigme de l'énonciation élaboré par Benveniste, Ducrot, Anscombre, Nølke et Culioli. Ils sont pour le cognitivisme de Kleiber, de Cadiot, de Fuchs et pour la Grammaire cognitive dérivés d'un esprit au fonctionnement mécaniste. Permettant de délimiter la forme et l'évolution des paradigmes scientifiques, l'analyse des théories donne à voir l'état actuel de la discipline et les questions qu'elle sera appelée à résoudre.

The feasibility of neuroimaging methods in marketing research

On July 17, 1990, President George Bush ssued “Proclamation #6158" which boldly declared the following ten years would be called the “Decade of the Brain” (Bush, 1990). Accordingly, the research mandates of all US federal biomedical institutions worldwide were redirected towards the study of the brain in general and cognitive neuroscience specifically. In 2008, one of the greatest legacies of this “Decade of the Brain” is the impressive array of techniques that can be used to study cortical activity. We now stand at a juncture where cognitive function can be mapped in the time, space and frequency domains, as and when such activity occurs. These advanced techniques have led to discoveries in many fields of research and clinical science, including psychology and psychiatry. Unfortunately, neuroscientific techniques have yet to be enthusiastically adopted by the social sciences. Market researchers, as specialized social scientists, have an unparalleled opportunity to adopt cognitive neuroscientific techniques and significantly redefine the field and possibly even cause substantial dislocations in business models. Following from this is a significant opportunity for more commercially-oriented researchers to employ such techniques in their own offerings. This report examines the feasibility of these techniques.

Serum neopterin levels and gallium transferrin binding in Parkinson's disease

The unconjugated pterin neopterin is secreted by macrophages activated by interferon-gamma and hence, the level of neopterin in serum may be used as a marker of a cellular immune response in a patient. Serum neopterin levels were measured by high performance liquid chromatography (HPLC) in 28 Parkinson's disease (PD) patients and 28 age and sex matched controls. The level of serum neopterin was significantly elevated in PD compared with controls suggesting immune activation in these patients. The level of neopterin was negatively correlated with the level of binding of gallium to transferrin (Tf) but unrelated to the level of iron binding. Hence, in PD, it is possible that a cellular immune response may be important in the pathogenesis of the disease. One effect of the cellular immune response may be a reduction in the binding of metals other than iron to Tf and this could also be a factor in PD.