Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil salts

Objectives Understanding the impact of the counterion on the properties of an acidic or basic drug may influence the choice of salt form, especially for less potent drugs with a high drug load per unit dose. The aim of this work was to determine the influence of the hydrogen bonding potential of the counterion on the crystal structure of salts of the poorly soluble, poorly compressible, acidic drug gemfibrozil and to correlate these with mechanical properties. Methods Compacts of the parent drug and the salts were used to determine Young's modulus of elasticity using beam bending tests. Crystal structures were determined previously from X-ray powder diffraction data. Key findings The free acid, tert-butylamine, 2-amino-2-methylpropan-1-ol and 2-amino-2-methylpropan-1, 3-diol salts had a common crystal packing motif of infinite hydrogen-bonded chains with cross-linking between pairs of adjacent chains. The tromethamine (trsi) salt, with different mechanical properties, had a two-dimensional sheet-like network of hydrogen bonds, with slip planes, forming a stiffer compact. Conclusions The type of counter ion is important in determining mechanical properties and could be selected to afford slip and plastic deformation. © 2010 Royal Pharmaceutical Society of Great Britain.

Concrete beams with stirrups subject to torsion, shear and bending

This thesis examines experimentally and theoretically the behaviour and ultimate strength of rectangular reinforced concrete members under combined torsion, shear and bending. The experimental investigation consists of the test results of 38 longitudinally and transversely reinforced concrete beams subjected to combined loads, ten beams of which were tested under pure torsion and self-weight. The behaviour of each test beam from application of the first increment of load until failure is presented. The effects of concrete strength, spacing of the stirrups, the amount of longitudinal steel and the breadth of the section on the ultimate torsional capacity are investigated. Based on the skew-bending mechanism, compatibility, and linear stress-strain relationship for the concrete and the steel, simple rational equations are derived for the three principal modes of failure for the following four types of failure observed in the tests: TYPE I Yielding the reinforcement, at failure, before crushing the concrete. TYPE II Yielding of the web steel only, at failure, before crushing the concrete. TYPE III Yielding of the longitudinal steel only, at failure, before crushing the concrete. TYPE IV Crushing of the concrete, at failure, before yielding of any of the reinforcement.