2 resultados para Quantitative systems pharmacology

em Publishing Network for Geoscientific


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The selection of metrics for ecosystem restoration programs is critical for improving the quality of monitoring programs and characterizing project success. Moreover it is oftentimes very difficult to balance the importance of multiple ecological, social, and economical metrics. Metric selection process is a complex and must simultaneously take into account monitoring data, environmental models, socio-economic considerations, and stakeholder interests. We propose multicriteria decision analysis (MCDA) methods, broadly defined, for the selection of optimal sets of metrics to enhance evaluation of ecosystem restoration alternatives. Two MCDA methods, a multiattribute utility analysis (MAUT), and a probabilistic multicriteria acceptability analysis (ProMAA), are applied and compared for a hypothetical case study of a river restoration involving multiple stakeholders. Overall, the MCDA results in a systematic, unbiased, and transparent solution, informing restoration alternatives evaluation. The two methods provide comparable results in terms of selected metrics. However, because ProMAA can consider probability distributions for weights and utility values of metrics for each criteria, it is suggested as the best option if data uncertainty is high. Despite the increase in complexity in the metric selection process, MCDA improves upon the current ad-hoc decision practice based on the consultations with stakeholders and experts, and encourages transparent and quantitative aggregation of data and judgement, increasing the transparency of decision making in restoration projects. We believe that MCDA can enhance the overall sustainability of ecosystem by enhancing both ecological and societal needs.

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The Imbrie and Kipp transfer function method (IKM) and the modern analog technique (MAT) are accepted tools for quantitative paleoenvironmental reconstructions. However, no uncomplicated, flexible software has been available to apply these methods on modern computer devices. For this reason the software packages PaleoToolBox, MacTransfer, WinTransfer, MacMAT, and PanPlot have been developed. The PaleoToolBox package provides a flexible tool for the preprocessing of microfossil reference and downcore data as well as hydrographic reference parameters. It includes procedures to randomize the raw databases; to switch specific species in or out of the total species list; to establish individual ranking systems and their application on the reference and downcore databasessemi; and to convert the prepared databases into the file formats of IKM and MAT software for estimation of paleohydrographic parameters.