Figure 1 Geomorphological map of proglacial area of Yala (Dakpatsen) Glacier, Langtang Himal, Nepal (pdf 500 kB)

A series of minor moraine ridges are observed on the till surface in the proglacial area of Yala Glacier, Nepal Himalaya. The till surface, which is often fluted, consists ofsix different till sheets. It lies present glacial margin and the bulky terminal moraine ridges. These till sheets correspond to six re-advance stages during the general retreat which followed Little Ice Age ad- vance which formed the bulky terminal moraine ridges. Field observations and till fabric analysis suggest that the minor moraine ridges of Yala Glacier seem to be formed annually, by ice push. On the assumption that their annual character was maintained for a long time, and that the time span needed for each re-advance was proportional to the height of terminal moraine of each till sheet, the dating of Little fee Age moraines was attempted. The results indicate that Little Ice Age advances occurred in 1815 and in 1843, roughly simultanously with those in Europe.

Phosphorylation levels of JAK2 after addition of increasing Epo-concentrations: model approach (Figure 5a)

The present dataset contain source data for Figure 5a from Schilling et al., 2009. Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. The authors combined quantitative data from erythropoietin-induced pathway activation in primary erythroid progenitor (colony-forming unit erythroid stage, CFU-E) cells with mathematical modelling, in order to predict and experimentally confirmed a distributive ERK phosphorylation mechanism in CFU-E cells. The authors found evidences that double-phosphorylated ERK1 attenuates proliferation beyond a certain activation level, whereas activated ERK2 enhances proliferation with saturation kinetics. Phosphorylation levels of JAK2 at 7 min after stimulation for Epo concentrations ranging from 0.1 to 1000 U/ml were simulated.

Modeled integrated responses of ppERK1 and ppERK2 of normal and elevated ERK1 and ERK2 levels (Figure 5b)

The present dataset contain source data for Figure 5b from Schilling et al., 2009. Cell fate decisions are regulated by the coordinated activation of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions of individual kinase isoforms are mostly unknown. The authors combined quantitative data from erythropoietin-induced pathway activation in primary erythroid progenitor (colony-forming unit erythroid stage, CFU-E) cells with mathematical modelling, in order to predict and experimentally confirmed a distributive ERK phosphorylation mechanism in CFU-E cells. The authors found evidences that double-phosphorylated ERK1 attenuates proliferation beyond a certain activation level, whereas activated ERK2 enhances proliferation with saturation kinetics. They show integrated responses of double-phosphorylated ERK1 and ERK2 that were calculated for different Epo concentrations for the original model as well as for models with elevated ERK1 or ERK2 levels.