1 resultado para Nelson, Frank Howard, 1869-1939.
em DigitalCommons@The Texas Medical Center
Filtro por publicador
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (12)
- Adam Mickiewicz University Repository (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (5)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (7)
- Aquatic Commons (10)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (14)
- Biblioteca Digital da Câmara dos Deputados (5)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (5)
- Biblioteca Digital de la Universidad Católica Argentina (3)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (10)
- Biodiversity Heritage Library, United States (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (39)
- Boston University Digital Common (1)
- Brock University, Canada (40)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CamPuce - an association for the promotion of science and humanities in African Countries (1)
- Carolina Law Scholarship Repository (1)
- CentAUR: Central Archive University of Reading - UK (27)
- Center for Jewish History Digital Collections (30)
- Central European University - Research Support Scheme (1)
- Chapman University Digital Commons - CA - USA (11)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (5)
- Cochin University of Science & Technology (CUSAT), India (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (7)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Dalarna University College Electronic Archive (4)
- Department of Computer Science E-Repository - King's College London, Strand, London (2)
- Digital Archives@Colby (5)
- Digital Howard @ Howard University | Howard University Research (19)
- Digital Peer Publishing (4)
- DigitalCommons@The Texas Medical Center (1)
- DigitalCommons@University of Nebraska - Lincoln (4)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (84)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (2)
- Duke University (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (68)
- Greenwich Academic Literature Archive - UK (2)
- Harvard University (1)
- Helda - Digital Repository of University of Helsinki (7)
- Indian Institute of Science - Bangalore - Índia (2)
- Infoteca EMBRAPA (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (4)
- Ministerio de Cultura, Spain (98)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (4)
- Portal de Revistas Científicas Complutenses - Espanha (2)
- Publishing Network for Geoscientific & Environmental Data (1)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (45)
- Queensland University of Technology - ePrints Archive (26)
- RDBU - Repositório Digital da Biblioteca da Unisinos (4)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (9)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- REPOSITORIO DIGITAL IMARPE - INSTITUTO DEL MAR DEL PERÚ, Peru (1)
- Repositorio Institucional de la Universidad Nacional Agraria (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (82)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- School of Medicine, Washington University, United States (10)
- South Carolina State Documents Depository (2)
- Universidad Autónoma de Nuevo León, Mexico (22)
- Universidad del Rosario, Colombia (14)
- Universidade de Lisboa - Repositório Aberto (3)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (4)
- Universidade Metodista de São Paulo (2)
- Universitat de Girona, Spain (9)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (2)
- Université de Lausanne, Switzerland (2)
- Université de Montréal, Canada (20)
- University of Connecticut - USA (8)
- University of Michigan (83)
- University of Southampton, United Kingdom (3)
- University of Washington (5)
- WestminsterResearch - UK (3)
Resumo:
Early diagnosis of Parkinson's disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect >50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p<0.005) and decreased fractional anisotropy (p<0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences (p < or = 0.002) and correlated with the numbers of SN dopaminergic neurons (r=-0.75, p=0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration.