1 resultado para Art and business -- Colorado -- Denver
em DigitalCommons@The Texas Medical Center
Filtro por publicador
- JISC Information Environment Repository (2)
- Repository Napier (3)
- Rhode Island School of Design (7)
- Aberystwyth University Repository - Reino Unido (1)
- Academic Research Repository at Institute of Developing Economies (6)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- Aquatic Commons (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (12)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (2)
- Argos - Repositorio Institucional de la Secretaría de Investigación y Postgrado de la Facultad de Humanidades y Ciencias Sociales de la Universidad Nacional de Misiones (1)
- Aston University Research Archive (46)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (3)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (34)
- Boston University Digital Common (1)
- Brock University, Canada (8)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- Cámara de Comercio de Bogotá, Colombia (1)
- Cambridge University Engineering Department Publications Database (19)
- CentAUR: Central Archive University of Reading - UK (28)
- Center for Jewish History Digital Collections (2)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (2)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (4)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (10)
- Dalarna University College Electronic Archive (2)
- Deakin Research Online - Australia (85)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (2)
- Digital Archives@Colby (1)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (44)
- Digital Commons at Florida International University (8)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (2)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (2)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (1)
- Ecology and Society (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- Escola Superior de Educação de Paula Frassinetti (1)
- Funes: Repositorio digital de documentos en Educación Matemática - Colombia (1)
- Greenwich Academic Literature Archive - UK (2)
- Harvard University (5)
- Helda - Digital Repository of University of Helsinki (8)
- Instituto Politécnico de Leiria (1)
- Ministerio de Cultura, Spain (8)
- Nottingham eTheses (1)
- Portal de Revistas Científicas Complutenses - Espanha (8)
- Publishing Network for Geoscientific & Environmental Data (1)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (38)
- Queensland University of Technology - ePrints Archive (217)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositorio de la Universidad de Cuenca (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (7)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (3)
- Repositorio Institucional Universidad de Medellín (1)
- Repositorio Institucional Universidad EAFIT - Medelin - Colombia (1)
- Royal College of Art Research Repository - Uninet Kingdom (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (7)
- Universidade de Lisboa - Repositório Aberto (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Montréal (1)
- Université de Montréal, Canada (7)
- University of Canberra Research Repository - Australia (1)
- University of Michigan (219)
- University of Queensland eSpace - Australia (9)
- University of Southampton, United Kingdom (1)
- University of Washington (1)
- WestminsterResearch - UK (1)
Resumo:
While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant. Gene transfer offers the prospect of highly specific therapies for childhood cancer. "Corrective" genes may be transferred to overcome the genetic abnormalities present in the precancerous cell. Alternatively, genes can be introduced to render the malignant cell sensitive to therapeutic drugs. The tumor can also be attacked by decreasing its blood supply with genes that inhibit vascular growth. Another possible approach is to modify normal tissues with genes that make them more resistant to conventional drugs and/or radiation, thereby increasing the therapeutic index. Finally, it may be possible to attack the tumor indirectly by using genes that modify the behavior of the immune system, either by making the tumor more immunogenic, or by rendering host effector cells more efficient. Several gene therapy applications have already been reported for pediatric cancer patients in preliminary Phase 1 studies. Although no major clinical success has yet been achieved, improvements in gene delivery technologies and a better understanding of mechanisms of tumor progression and immune escape have opened new perspectives for the cure of pediatric cancer by combining gene therapy with standard therapeutic available treatments.