Realistic Single Cell Modeling – from Experiment to Simulation

This tutorial gives a step by step explanation of how one uses experimental data to construct a biologically realistic multicompartmental model. Special emphasis is given on the many ways that this process can be imprecise. The tutorial is intended for both experimentalists who want to get into computer modeling and for computer scientists who use abstract neural network models but are curious about biological realistic modeling. The tutorial is not dependent on the use of a specific simulation engine, but rather covers the kind of data needed for constructing a model, how they are used, and potential pitfalls in the process.

Simulating in vivo-like Synaptic Input Patterns in Multicompartmental Models

In the laboratory of Dr. Dieter Jaeger at Emory University, we use computer simulations to study how the biophysical properties of neurons—including their three-dimensional structure, passive membrane resistance and capacitance, and active membrane conductances generated by ion channels—affect the way that the neurons transfer synaptic inputs into the action potential streams that represent their output. Because our ultimate goal is to understand how neurons process and relay information in a living animal, we try to make our computer simulations as realistic as possible. As such, the computer models reflect the detailed morphology and all of the ion channels known to exist in the particular neuron types being simulated, and the model neurons are tested with synaptic input patterns that are intended to approximate the inputs that real neurons receive in vivo. The purpose of this workshop tutorial was to explain what we mean by ‘in vivo-like’ synaptic input patterns, and how we introduce these input patterns into our computer simulations using the freely available GENESIS software package (http://www.genesis-sim.org/GENESIS). The presentation was divided into four sections: first, an explanation of what we are talking about when we refer to in vivo-like synaptic input patterns

Mitarbeiterqualifizierung in der virtuellen Realität - Implementierung und Evaluation einer didaktischen Simulationsanwendung

Virtuelle Teamtrainingsanwendungen sind im militärischen Bereich seit über 20 Jahren mit großem Erfolg im Einsatz. Bei geeigneten Randbedingungen schafft dieses Qualifizierungsmedium neben einer erheblichen Reduzierung von Ausbildungsdauer und -kosten beachtliche Vorteile hinsichtlich der einhergehenden Ausbildungsqualität. Im Rahmen des Bayerischen Forschungsverbundes ForLog wird in Kooperation des Lehrstuhls für Fördertechnik Materialfluss Logistik (fml) und der Ray Sono AG das Potenzial entsprechender Qualifizierungsansätze im zivilen Industriesektor praxisnah untersucht.

Enforcement of the GNU GPL in Germany and Europe

GPL enforcement is successful in Europe. In several court decisions and out of court settlements the license conditions of the GPL have been successfully enforced. In particular, embedded systems are the main focus of such compliance activities. The article describes the practice of enforcement activities and the legal prerequisites under the application of German law.