1 resultado para ultrasonic-vocalizations
em Digital Knowledge Repository of Central Drug Research Institute
Filtro por publicador
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberdeen University (2)
- Abertay Research Collections - Abertay University’s repository (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (15)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (3)
- Aquatic Commons (5)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (2)
- Aston University Research Archive (21)
- B-Digital - Universidade Fernando Pessoa - Portugal (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (23)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (9)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (11)
- Bioline International (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (26)
- Boston University Digital Common (2)
- Brock University, Canada (14)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (50)
- CentAUR: Central Archive University of Reading - UK (23)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (67)
- Cochin University of Science & Technology (CUSAT), India (10)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (44)
- Digital Archives@Colby (1)
- Digital Commons - Michigan Tech (1)
- Digital Knowledge Repository of Central Drug Research Institute (1)
- DigitalCommons - The University of Maine Research (2)
- DigitalCommons@University of Nebraska - Lincoln (2)
- Diposit Digital de la UB - Universidade de Barcelona (6)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (7)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- eScholarship Repository - University of California (1)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (2)
- Helda - Digital Repository of University of Helsinki (2)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (2)
- Indian Institute of Science - Bangalore - Índia (109)
- Instituto de Engenharia Nuclear, Brazil - Carpe dIEN (4)
- Instituto Politécnico do Porto, Portugal (2)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Massachusetts Institute of Technology (2)
- National Center for Biotechnology Information - NCBI (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Publishing Network for Geoscientific & Environmental Data (1)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (50)
- Queensland University of Technology - ePrints Archive (61)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (7)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (3)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (271)
- SAPIENTIA - Universidade do Algarve - Portugal (3)
- School of Medicine, Washington University, United States (2)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (4)
- Universidad Politécnica de Madrid (11)
- Universidade Federal do Pará (8)
- Universidade Federal do Rio Grande do Norte (UFRN) (13)
- Universitat de Girona, Spain (3)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (4)
- Université de Montréal, Canada (8)
- University of Michigan (11)
- University of Queensland eSpace - Australia (7)
- University of Washington (1)
Resumo:
A novel class of phospholipase-resisting phosphatidylcholine analogs, in which the C-2 ester group or both C-1 and C-2 ester groups have been replaced by carbamyloxy functions (-NH-C-O-), have been synthesized. These lipids were not degraded by phospholipase A2 while complete hydrolysis occurred with phospholipase C. Ultrasonic irradiation of the aqueous dispersions of the phospholipids in the presence as well as in the absence of cholesterol resulted in the formation of closed bilayer structures as evidenced by negative staining electron microscopy and also by their ability to entrap [14C]glucose. The leakage rates of glucose at 37°C from liposomes of these compounds have also been measured. Liposomes consisting of 1,2-dipentadecanylcarbamyloxy-sn-glycero- 3-phosphorylcholine were found to be more leaky (2.1 %/h) as compared to the liposomes of 1-palmitoyl-2-pentadecanylcarbamyloxy-sn -glycero-3-phosphoryl- choline (O.5%/h). Moreover, inclusion of cholesterol (33 mol%) into the bilayers of the former phospholipid had no effect on the leakage rate (2.4%/h) while it effectively reduced permeability of the latter (O.22%/h). These phosphatidylcholines are useful for studying the possible role of phospholipases in the capture and lysis of liposomes in vivo.