Highly Substituted Isoxazoles: The Baylis-Hillman reaction of substituted 4-isoxazolecarbaldehydes and attempted cyclization to isoxazole-annulated derivatives

In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarboxaldehydes, the reactions of substituted 4-isoxazolecarboxaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annealed derivatives from these Baylis-Hillman adducts involving SNR’-SNAr substitu-tion strategy are also described.

Facile Baylis-Hillman reaction of substituted 3-isoxazolecarbaldehydes: The impact of proximal heteroatom within a heterocycle on the acceleration of reaction

The fast and facile Baylis-Hillman reaction in substi-tuted 3-isoxazolecarbaldehydes confirms the impact of the proxi-mal heteroatom within a heterocycle towards enhanced reactivity of the formyl group for this reaction

Studies on the Baylis-Hillman reaction of pyrazolecarbaldehydes under the influence of DABCO: Positional effect on the reactivity of the formyl group

Results of the study to assess the difference in reactivity of the formyl group present at various positions in substituted pyrazolecarbaldehydes for the Baylis-Hillman reaction under the influence of DABCO are described.

Sodium hydride-mediated cascade reaction towards the synthesis of 1,5-disubstituted uracil from cyanamides derived from the Baylis-Hillman ad-ducts

Sodium hydride-mediated cascade reaction towards the synthesis of 1,5-disubstituted uracil from cyanamides derived from the Baylis-Hillman ad-ducts

A reinvestigation into the reaction of NH4OAc with acetyl derivatives of Bay-lis-Hillman adducts: Formation of tertiary and secondary allyl amines in-stead of primary allyl amines

A reinvestigation into the reaction between ammonium acetate and the acetyl derivatives of Baylis-Hillman adducts has led us to conclude that the products obtained are tertiary and secondary allyl amines and not the primary allyl amines. The unambiguous assignment of the structure of products using chemical and spectroscopic methods is described