2 resultados para Step-stress accelerated life testing
em Collection Of Biostatistics Research Archive
Resumo:
One of the conclusions reached during the Congressionally mandated National Acid Precipitation Program (NAPAP) was that, compared to ozone and other stress factors, the direct effects of acidic deposition on forest health and productivity were likely to be relatively minor. However, the report also concluded “the possibility of long-term (several decades) adverse effects on some soils appears realistic” (Barnard et al. 1990). Possible mechanisms for these long-term effects include: (1) accelerated leaching of base cations from soils and foliage, (2) increased mobilization of aluminum (Al) and other metals such as manganese (Mn), (3) inhibition of soil biological processes, including organic matter decomposition, and (4) increased bioavailability of nitrogen (N).
Resumo:
This paper introduces a novel approach to making inference about the regression parameters in the accelerated failure time (AFT) model for current status and interval censored data. The estimator is constructed by inverting a Wald type test for testing a null proportional hazards model. A numerically efficient Markov chain Monte Carlo (MCMC) based resampling method is proposed to simultaneously obtain the point estimator and a consistent estimator of its variance-covariance matrix. We illustrate our approach with interval censored data sets from two clinical studies. Extensive numerical studies are conducted to evaluate the finite sample performance of the new estimators.