1 resultado para Dionysius, B. R. (Brett Raymond), 1969- -- Criticism and interpretation
em Collection Of Biostatistics Research Archive
Filtro por publicador
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Aberdeen University (1)
- Aberystwyth University Repository - Reino Unido (2)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (3)
- Applied Math and Science Education Repository - Washington - USA (1)
- Aquatic Commons (8)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (1)
- Archive of European Integration (11)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (1)
- Aston University Research Archive (11)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (6)
- Biodiversity Heritage Library, United States (6)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (31)
- Boston University Digital Common (1)
- Brock University, Canada (6)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (14)
- CentAUR: Central Archive University of Reading - UK (25)
- Center for Jewish History Digital Collections (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (12)
- Cochin University of Science & Technology (CUSAT), India (1)
- Collection Of Biostatistics Research Archive (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (4)
- CORA - Cork Open Research Archive - University College Cork - Ireland (11)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (77)
- Digital Archives@Colby (7)
- Digital Commons @ DU | University of Denver Research (102)
- Digital Commons @ Winthrop University (1)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (2)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (3)
- Duke University (2)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (25)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (1)
- Greenwich Academic Literature Archive - UK (1)
- Harvard University (7)
- Helda - Digital Repository of University of Helsinki (34)
- Indian Institute of Science - Bangalore - Índia (28)
- Instituto Politécnico de Castelo Branco - Portugal (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- Massachusetts Institute of Technology (2)
- Memorial University Research Repository (1)
- Ministerio de Cultura, Spain (2)
- National Center for Biotechnology Information - NCBI (7)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (10)
- Portal de Revistas Científicas Complutenses - Espanha (5)
- Publishing Network for Geoscientific & Environmental Data (15)
- QSpace: Queen's University - Canada (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (26)
- Queensland University of Technology - ePrints Archive (50)
- Repositório digital da Fundação Getúlio Vargas - FGV (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade Tecnológica Federal do Paraná (RIUT) (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (220)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- Universidad Autónoma de Nuevo León, Mexico (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (4)
- Universidade Complutense de Madrid (1)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (1)
- Universitat de Girona, Spain (10)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (2)
- Université de Montréal, Canada (2)
- University of Connecticut - USA (1)
- University of Michigan (96)
- University of Queensland eSpace - Australia (22)
- University of Washington (2)
Resumo:
Genotyping platforms such as Affymetrix can be used to assess genotype-phenotype as well as copy number-phenotype associations at millions of markers. While genotyping algorithms are largely concordant when assessed on HapMap samples, tools to assess copy number changes are more variable and often discordant. One explanation for the discordance is that copy number estimates are susceptible to systematic differences between groups of samples that were processed at different times or by different labs. Analysis algorithms that do not adjust for batch effects are prone to spurious measures of association. The R package crlmm implements a multilevel model that adjusts for batch effects and provides allele-specific estimates of copy number. This paper illustrates a workflow for the estimation of allele-specific copy number, develops markerand study-level summaries of batch effects, and demonstrates how the marker-level estimates can be integrated with complimentary Bioconductor software for inferring regions of copy number gain or loss. All analyses are performed in the statistical environment R. A compendium for reproducing the analysis is available from the author’s website (http://www.biostat.jhsph.edu/~rscharpf/crlmmCompendium/index.html).