Animal models for peri-implant mucositis and peri-implantitis

The treatment of infectious diseases affecting osseointegrated implants in function has become a demanding issue in implant dentistry. Since the early 1990s, preclinical data from animal studies have provided important insights into the etiology, pathogenesis and therapy of peri-implant diseases. Established lesions in animals have shown many features in common with those found in human biopsy material. The current review focuses on animal studies, employing different models to induce peri-implant mucositis and peri-implantitis.

Wound models for periodontal and bone regeneration: the role of biologic research

The ultimate goals of periodontal therapy remain the complete regeneration of those periodontal tissues lost to the destructive inflammatory-immune response, or to trauma, with tissues that possess the same structure and function, and the re-establishment of a sustainable health-promoting biofilm from one characterized by dysbiosis. This volume of Periodontology 2000 discusses the multiple facets of a transition from therapeutic empiricism during the late 1960s, toward regenerative therapies, which is founded on a clearer understanding of the biophysiology of normal structure and function. This introductory article provides an overview on the requirements of appropriate in vitro laboratory models (e.g. cell culture), of preclinical (i.e. animal) models and of human studies for periodontal wound and bone repair. Laboratory studies may provide valuable fundamental insights into basic mechanisms involved in wound repair and regeneration but also suffer from a unidimensional and simplistic approach that does not account for the complexities of the in vivo situation, in which multiple cell types and interactions all contribute to definitive outcomes. Therefore, such laboratory studies require validatory research, employing preclinical models specifically designed to demonstrate proof-of-concept efficacy, preliminary safety and adaptation to human disease scenarios. Small animal models provide the most economic and logistically feasible preliminary approaches but the outcomes do not necessarily translate to larger animal or human models. The advantages and limitations of all periodontal-regeneration models need to be carefully considered when planning investigations to ensure that the optimal design is adopted to answer the specific research question posed. Future challenges lie in the areas of stem cell research, scaffold designs, cell delivery and choice of growth factors, along with research to ensure appropriate gingival coverage in order to prevent gingival recession during the healing phase.

Sportvereine als Interessenorganisationen?! – Ursachen und Auswirkungen von Ziel-Interessen-Divergenzen in freiwilligen Sportorganisationen

Für Sportvereine als Interessenorganisationen scheint die Rückbindung der Vereinsziele an die Mitgliederinteressen von zentraler Bedeutung zu sein. In der Vereinsrealität dürfte aber diese Rückbindung nur teilweise gewährleistet sein und folglich Ziel-Interessen-Divergenzen eher die Norm als die Ausnahme darstellen. Vor diesem Hintergrund stellt sich die Frage, welche Ursachen für Ziel-Interessen-Divergenzen verantwortlich zu machen sind und welche Auswirkungen sich daraus für die Vereine ergeben. Dieser Frage geht der vorliegende Beitrag nach, indem auf der Grundlage des Akteurtheoretischen Mehr-Ebenen-Modells zur Analyse der Entwicklung von Sportvereinen die struktur- und handlungsbedingten Ursachen und Auswirkungen von Divergenzen auf der Vereins- und Mitgliederebene beleuchtet werden. Mit Blick auf die Ursachen wurde der Einfluss der korporativen Vereinsstrukturen und der individuellen Handlungsorientierungen der Mitglieder auf Divergenzen untersucht. Die Befunde hierzu zeigen, dass Divergenzen einerseits durch einem zunehmenden Differenzierungs- und Hierarchisierungsgrad (z.B. Vereinsgröße, Umweltvernetzung, Oligarchisierung) begünstigt werden und andererseits vor allem bei einer primären Verfolgung von Eigeninteressen der Mitglieder auftreten. Hinsichtlich der Auswirkungen wurden die individuellen Mitgliederreaktionen und die korporativen Vereinsreaktionen auf Divergenzen analysiert. Diesbezüglich zeigen die Befunde, dass sowohl die Mitglieder als auch die Vereinsführung überwiegend konstruktiv auf Divergenzen reagieren (z.B. durch Problemansprache, Vertrauen, Kompromissfindung), so dass es vielen Vereinen offenbar relativ gut gelingt, Ziel-Interessen-Divergenzen bis zu einem gewissen Grad sowohl aushalten als auch aufarbeiten zu können.

Cultural capital and smoking in young adults: applying new indicators to explore social inequalities in health behaviour.

BACKGROUND Associations between social status and health behaviours are well documented, but the mechanisms involved are less understood. Cultural capital theory may contribute to a better understanding by expanding the scope of inequality indicators to include individuals' knowledge, skills, beliefs and material goods to examine how these indicators impact individuals' health lifestyles. We explore the structure and applicability of a set of cultural capital indicators in the empirical exploration of smoking behaviour among young male adults. METHODS We analysed data from the Swiss Federal Survey of Adolescents (CH-X) 2010-11 panel of young Swiss males (n = 10 736). A set of nine theoretically relevant variables (including incorporated, institutionalized and objectified cultural capital) were investigated using exploratory factor analysis. Regression models were run to observe the association between factor scores and smoking outcomes. Outcome measures consisted of daily smoking status and the number of cigarettes smoked by daily smokers. RESULTS Cultural capital indicators aggregated in a three-factor solution representing 'health values', 'education and knowledge' and 'family resources'. Each factor score predicted the smoking outcomes. In young males, scoring low on health values, education and knowledge and family resources was associated with a higher risk of being a daily smoker and of smoking more cigarettes daily. CONCLUSION Cultural capital measures that include, but go beyond, educational attainment can improve prediction models of smoking in young male adults. New measures of cultural capital may thus contribute to our understanding of the social status-based resources that individuals can use towards health behaviours.

Calibrating a CGE model with NTBs that Incorporates Standard Models of Modern Trade Theory

We propose a way to incorporate NTBs for the four workhorse models of the modern trade literature in computable general equilibrium models (CGEs). CGE models feature intermediate linkages and thus allow us to study global value chains (GVCs). We show that the Ethier-Krugman monopolistic competition model, the Melitz firm heterogeneity model and the Eaton and Kortum model can be defined as an Armington model with generalized marginal costs, generalized trade costs and a demand externality. As already known in the literature in both the Ethier-Krugman model and the Melitz model generalized marginal costs are a function of the amount of factor input bundles. In the Melitz model generalized marginal costs are also a function of the price of the factor input bundles. Lower factor prices raise the number of firms that can enter the market profitably (extensive margin), reducing generalized marginal costs of a representative firm. For the same reason the Melitz model features a demand externality: in a larger market more firms can enter. We implement the different models in a CGE setting with multiple sectors, intermediate linkages, non-homothetic preferences and detailed data on trade costs. We find the largest welfare effects from trade cost reductions in the Melitz model. We also employ the Melitz model to mimic changes in Non tariff Barriers (NTBs) with a fixed cost-character by analysing the effect of changes in fixed trade costs. While we work here with a model calibrated to the GTAP database, the methods developed can also be applied to CGE models based on the WIOD database.