Development of an LC-MS/MS method for the quantitation of 55 compounds prescribed in combined cardiovascular therapy

This paper reports an LC-MS/MS method with positive electrospray ionization for the screening of commonly prescribed cardiovascular drugs in human plasma, including compounds with antihypertensive (57), antidiabetic (12), hypolipemiant (5), anticoagulant (2) and platelet anti-aggregation (2) effects. Sample treatment consisted of a simple protein precipitation with MeOH/0.1 M ZnSO₄ (4:1, v/v) solution after the addition of internal standard, followed by evaporation and reconstitution. Analytes separation was performed on a Polar-RP column (150 m x 2 mm, 4 μm) using a gradient elution of 15 min. The MS system was operated in MRM mode, monitoring one quantitation and one confirmation transition for each analyte. The recovery of the protein precipitation step ranged from 50 to 70% for most of the compounds, while some were considerably affected by matrix effects. Since several analytes fulfilled the linearity, accuracy and precision values required by the ICH guidelines, the method proved to be suitable for their quantitative analysis. The limits of quantitation varied from 0.38 to 9.1 μg/L and the limits of detection from 0.12 to 5.34 μg/L. The method showed to be suitable for the detection of plasma samples of patients under cardiovascular treatment with the studied drugs, and for 55 compounds reliable quantitative results could be obtained.

Motivation und Emotion. Allgemeine Psychologie für Bachelor

Ziellos und gefühllos – so wäre unser Leben ohne Motivation und Emotion! Ziele geben unserem Leben Sinn und Struktur, sie treiben uns zu großen Anstrengungen und erstaunlichen Leistungen an. Sie richten unser Verhalten auf die Dinge aus, die uns wichtig sind. – Und was uns wichtig ist, wofür sich die ganze Anstrengung lohnt, das sagen uns unsere Emotionen. Die „Module“ Motivation und Emotion gehören somit zu den spannendsten Fächern der Psychologie und stellen wichtige Grundlageninformationen für die psychologischen Anwendungsfächer zur Verfügung. Dieses Lehrbuch beantwortet die wichtigsten Fragen der Motivations- und Emotionspsychologie kompakt und verständlich.

Computer-assisted virtual autopsy using surgical navigation techniques

UNLABELLED OBJECTIVE; Virtual autopsy methods, such as postmortem CT and MRI, are increasingly being used in forensic medicine. Forensic investigators with little to no training in diagnostic radiology and medical laypeople such as state's attorneys often find it difficult to understand the anatomic orientation of axial postmortem CT images. We present a computer-assisted system that permits postmortem CT datasets to be quickly and intuitively resliced in real time at the body to narrow the gap between radiologic imaging and autopsy. CONCLUSION Our system is a potentially valuable tool for planning autopsies, showing findings to medical laypeople, and teaching CT anatomy, thus further closing the gap between radiology and forensic pathology.

Whole of Government Approach for Institutional and Policy Coherence

The comprehensive structure of cooperation at domestic level reflects on bilateral, regional and global level.

Strengthening the Migration-Development Nexus through Improved Policy and Institutional Coherence

The complexity of migration issues is clearly reflected by states diverging national migration policy interests that exists within one state. In line with the Swiss Report on International Cooperation on Migration of the Swiss Federal Council , this complexity requires close coordination and cooperation between the governmental institutions and all offices. Only through a close and coherent cooperation between all governmental actors involved in migration issues the migration-development nexus can be strength. The present paper will suggest how intergovernmental cooperation can lead to better policy coherence in migration by interlinking all actors involved.

Swiss Migration Partnerships

Workshop "Fostering the nexus of migration, human rights, trade and investment for development" Introductory note on Swiss Migrations Partnerships and the possibilities for fostering the nexus of migration, human rights, trade and investment for more development This presentation was held during a workshop "Fostering the nexus of migration, human rights, trade and investment for development".

The doctrine of multilayered governance: The Example of Swiss Foreign Migration Policy

The New Swiss interdepartemental cooperation structure results in a new setting in negotiations and stimulates the counterpart or for the same setting and at least for the same domestic cooperation.