Desarrollo endógeno sustentable: camino para re-actualizar el "Vivir Bien" en el contexto de la revolución democrática y cultural de Bolivia

Un conjuto de autores Bolivianos y Latinoamericanos reflexionan acerca de los alcances del paradigma del Vivir Bien y sus posibilidades para constituirse en el soporte ético que ilumine un nuevo paradigma de producción y reproducción de la realidad social. Los autores exploran sus dimensiones semánticas y filosóficas, así como los horizones utópicos que propone este paradigma. También hacen un análisis de los patrones de desarrollo en cursos, y cómo se viene aplicando en Bolivia este paradigma. Esta publicación es promovida por el Postgrado en Ciencias del Desarrollo de la Universidad Mayor de San Andrés (cides-umsa) y el Departamento de Economía de la Universidad de Roma “ La Sapienza ”, en el marco de un Convenio de Colaboración académica entre ambas Universidades.

Argemone mexicana decoction for the treatment of uncomplicated falciparum malaria

A prospective, dose-escalating, quasi-experimental clinical trial was conducted with a traditional healer using a decoction of Argemone mexicana for the treatment of malaria in Mali. The remedy was prescribed in three regimens: once daily for 3 days (Group A; n=23); twice daily for 7 days (Group B; n=40); and four times daily for the first 4 days followed by twice daily for 3 days (Group C; n=17). Thus, 80 patients were included, of whom 80% were aged<5 years and 25% were aged<1 year. All presented to the traditional healer with symptoms of malaria and had a Plasmodium falciparum parasitaemia>2000/microl but no signs of severe malaria. The proportions of adequate clinical response (ACR) at Day 14 were 35%, 73% and 65% in Groups A, B and C, respectively (P=0.011). At Day 14, overall proportions of ACR were lower in children aged<1 year (45%) and higher in patients aged>5 years (81%) (P=0.027). Very few patients had complete parasite clearance, but at Day 14, 67% of patients with ACR had a parasitaemia<2000/microl. No patient needed referral for severe disease. Only minor side effects were observed. Further research should determine whether this local resource could represent a first-aid home treatment in remote areas.

Prácticas discursivas y estereotipos: la figura del naco en la sociedad mexicana actual

En las sociedades actuales, marcadas por la movilidad, la migración, la desigualdad y una compleja red de relaciones sociales, el discurso cum- ple una función esencial como pieza fundamental en la constitución de prácticas sociales y en nuestra interacción diaria, en la que, entre mu- chas otras cosas, expresamos nuestra identidad o rechazo social. Justamente lo que me interesa en esta contribución es estudiar de qué manera las diferentes prácticas discursivas contribuyen a construir, reanalizar o subvertir estereotipos sociales y con qué funciones. Me val- dré para ello del estereotipo del naco y su representación en la sociedad mexicana actual. La figura del naco se presta perfectamente para estu- diar la importancia del estereotipo en la sociedad porque es controver- sial y ambivalente, pues suscita tanto rechazo como identificación. Es objeto de parodia y de risa, actuando a su vez como símbolo del genui- nísimo proletariado a la mexicana.

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.

The protozoan Leishmania mexicana parasite causes chronic non-healing cutaneous lesions in humans and mice with poor parasite control. The mechanisms preventing the development of a protective immune response against this parasite are unclear. Here we provide data demonstrating that parasite sequestration by neutrophils is responsible for disease progression in mice. Within hours of infection L. mexicana induced the local recruitment of neutrophils, which ingested parasites and formed extracellular traps without markedly impairing parasite survival. We further showed that the L. mexicana-induced recruitment of neutrophils impaired the early recruitment of dendritic cells at the site of infection as observed by intravital 2-photon microscopy and flow cytometry analysis. Indeed, infection of neutropenic Genista mice and of mice depleted of neutrophils at the onset of infection demonstrated a prominent role for neutrophils in this process. Furthermore, an increase in monocyte-derived dendritic cells was also observed in draining lymph nodes of neutropenic mice, correlating with subsequent increased frequency of IFNγ-secreting T helper cells, and better parasite control leading ultimately to complete healing of the lesion. Altogether, these findings show that L. mexicana exploits neutrophils to block the induction of a protective immune response and impairs the control of lesion development. Our data thus demonstrate an unanticipated negative role for these innate immune cells in host defense, suggesting that in certain forms of cutaneous leishmaniasis, regulating neutrophil recruitment could be a strategy to promote lesion healing.