75 resultados para RODRIGUEZ, MARTIN

em BORIS: Bern Open Repository and Information System - Berna - Suiça


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Am 10. September 2010 fand in Bern die erste Schweizerische Tagung für Zivilverfahrensrecht des Instituts für Internationales Privatrecht und Verfahrensrecht der Universität Bern statt. Die Tagung mit dem Titel "Internationaler Zivilprozess 2011" befasste sich mit dem Zusammenspiel der am 1.1.2011 in Kraft tretenden neuen oder revidierten Erlasse (ZPO, revLugÜ, und revSchKG) im Rahmen des internationalen Zivilprozesses. Der Tagungsband enthält auf den Tagungsvorträgen basierende Beiträge namhafter Autoren zu aktuellen und praxisrelevanten Themen des neuen internationalen Zivilprozesses, namentlich zum neuen Arrestrecht, zur Behandlung von Zustellungsmängeln unter dem revLugÜ, zum Zahlungsbefehl im Lichte der revLugÜ-Zuständigkeiten, zur vollstreckbaren öffentliche Urkunde sowie zur Rechtshängigkeit und zur Streitgenossenschaft im internationalen Verhältnis. Der Tagungsband "Internationaler Zivilprozess 2011" eröffnet eine neue Schriftenreihe zum Internationalen Privatrecht und Verfahrensrecht.

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In this study, we have investigated the role of CD69, an early inducible leukocyte activation receptor, in murine dendritic cell (DC) differentiation, maturation, and migration. Skin DCs and DC subsets present in mouse lymphoid organs express CD69 in response to maturation stimuli. Using a contact sensitization model, we show that skin DCs migrated more efficiently to draining lymph nodes (LNs) in the absence of CD69. This was confirmed by subcutaneous transfer of CD69-/- DCs, which presented an increased migration to peripheral LNs. Two-photon microscopy analysis showed that once DCs reached the LNs, CD69 deficiency did not alter DC interstitial motility in the LNs. Chemotaxis to sphingosine-1-phosphate (S1P) was enhanced in CD69-/- DCs compared with wild-type DCs. Accordingly, we detected a higher expression of S1P receptor type-1 (S1P(1)) by CD69-/- DCs, whereas S1P(3) expression levels were similar in wild-type and CD69-/- DCs. Moreover, in vivo treatment with S1P analogs SEW2871 and FTY720 during skin sensitization reduced skin DC migration to peripheral LNs. These results suggest that CD69 regulates S1P-induced skin DC migration by modulating S1P(1) function. Together, our findings increase our knowledge on DC trafficking patterns in the skin, enabling the development of new directed therapies using DCs for antigen (Ag) delivery.

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Site-selective spectroscopy in hexagonal beta-NaYF4:Er3+,Yb3+ has revealed different environments for Er3+ ions (multisite formation). The low-temperature S-4(3/2) -> (I15/2Er3+)-I-4 green emission depends on the excitation wavelength associated with the F-4(7/2) Er3+ level. We have studied the effect of hydrostatic pressure on the green, red, and blue Er3+ emission upon NIR excitation at similar to 980 nm, in order to establish the role played by energy resonance conditions and the multiple Er3+ sites due to the disordered structure for the upconversion (UC) process (energy tuning). The variation of photoluminescence spectra and lifetimes as a function of pressure and temperature reveals that the origin of the high green UC efficiency of the beta-NaYF4:Er3+,Yb3+ compound is mainly due to the multisite distribution, and the low phonon energy of the host lattice.