Serum glycodelin pattern during the menstrual cycle in healthy young women

OBJECTIVE: Glycodelin (PP14) is produced by the epithelium of the endometrium and its determination in the serum is used for functional evaluation of this tissue. Given the complex regulation and the combined contraceptive and immunosuppressive roles of glycodelin, the current lack of normal values for its serum concentration in the physiological menstrual cycle, derived from a large sample number, is a problem. We have therefore established reference values from over 600 sera. DESIGN: Retrospective study using banked serum samples. SETTING: University hospital. METHODS: Measurement of blood samples daily or every second day during one full cycle. MAIN OUTCOME MEASURES: Serum concentrations of glycodelin and normal values for every such one- or two-day interval were calculated. Late luteal phase glycodelin levels were compared with ovarian hormones. Follicular phase levels were compared with stimulated cycles from patients undergoing in vitro fertilization. RESULTS: Glycodelin concentrations were low around ovulation. Highest levels were observed at the end of the luteal phase; the glycodelin serum peak was reached 6-8 days after the one for progesterone. Late luteal glycodelin levels correlated negatively with the body mass index and positively with the progesterone level earlier in the secretory (mid-luteal) phase in the same woman. No associations with other ovarian hormones were observed. Follicular phase glycodelin levels were higher in the spontaneous than in the in vitro fertilization cycles. CONCLUSIONS: Normal values taken at two- or one-day intervals demonstrate the very late appearance of high serum glycodelin levels during the physiological menstrual cycle and their correlation with progesterone occurring earlier in the cycle.

SCAD: Sensor Context-aware Adaptive Duty-cycled Beaconless Opportunistic Routing for WSNs

Low quality of wireless links leads to perpetual transmission failures in lossy wireless environments. To mitigate this problem, opportunistic routing (OR) has been proposed to improve the throughput of wireless multihop ad-hoc networks by taking advantage of the broadcast nature of wireless channels. However, OR can not be directly applied to wireless sensor networks (WSNs) due to some intrinsic design features of WSNs. In this paper, we present a new OR solution for WSNs with suitable adaptations to their characteristics. Our protocol, called SCAD-Sensor Context-aware Adaptive Duty-cycled beaconless opportunistic routing protocol is a cross-layer routing approach and it selects packet forwarders based on multiple sensor context information. To reach a balance between performance and energy-efficiency, SCAD adapts the duty-cycles of sensors according to real-time traffic loads and energy drain rates. We compare SCAD against other protocols through extensive simulations. Evaluation results show that SCAD outperforms other protocols in highly dynamic scenarios.