2 resultados para AH-1

em BORIS: Bern Open Repository and Information System - Berna - Suiça


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Im vorliegenden Essay wird eine Lesart des viel diskutierten Paris-Berichts von Rifāʿa aṭ-Ṭahṭāwī vorgestellt. Kontrastierend zu der Annahme, Ṭahṭāwī habe eine Reise aus einer Kultur in eine andere unternommen, soll hier dargelegt werden, wie sich aus dem Text des Ägypters ein eigenes Kulturverständnis erschließen lässt. Besonders Ṭahṭāwīs Bemühungen um die Übersetzung des französischen Begriffs 'civilisation' deuten auf ein plurales Verständnis von 'Kultur'. Denn im Text lassen sich diejenigen Dimensionen des Begriffs 'Kultur' finden, die auch aus der europäischen Geistesgeschichte rekonstruiert werden können: Kultur als bestimmter Lebensstil, als Prozessbegriff zur Beschreibung gesellschaftlicher Entwicklung und als kreative oder künstlerische Aktivität.

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The Three Gorges Reservoir (TGR), created in consequence of the Yangtze River's impoundment by the Three Gorges Dam, faces numerous anthropogenic impacts that challenge its unique ecosystem. Organic pollutants, particularly aryl hydrocarbon receptor (AhR) agonists, have been widely detected in the Yangtze River, but only little research was yet done on AhR-mediated activities. Hence, in order to assess effects of organic pollution, with particular focus on AhR-mediated activities, several sites in the TGR area were examined applying the "triad approach". It combines chemical analysis, in vitro, in vivo and in situ investigations to a holistic assessment. Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011/2012, respectively, to identify relevant endpoints. Sediment was tested in vitro with the ethoxyresorufin-O-deethylase (EROD) induction assay, and in vivo with the Fish Embryo Toxicity Test and Sediment Contact Assay with Danio rerio. Activities of phase I (EROD) and phase II (glutathione-S-transferase) biotransformation enzymes, pollutant metabolites and histopathological alterations were studied in situ in P. vachellii. EROD induction was tested in vitro and in situ to evaluate possible relationships. Two sites, near Chongqing and Kaixian city, were identified as regional hot-spots and further investigated in 2013. The sediments induced in the in vitro/in vivo bioassays AhR-mediated activities and embryotoxic/teratogenic effects - particularly on the cardiovascular system. These endpoints could be significantly correlated to each other and respective chemical data. However, particle-bound pollutants showed only low bioavailability. The in situ investigations suggested a rather poor condition of P. vachellii, with histopathological alterations in liver and excretory kidney. Fish from Chongqing city exhibited significant hepatic EROD induction and obvious parasitic infestations. The polycyclic aromatic hydrocarbon (PAH) metabolite 1-hydroxypyrene was detected in bile of fish from all sites. All endpoints in combination with the chemical data suggest a pivotal role of PAHs in the observed ecotoxicological impacts.