Non-canonical actions of Nogo-A and its receptors

Nogo-A is a myelin associated protein and one of the most potent neurite growth inhibitors in the central nervous system. Interference with Nogo-A signaling has thus been investigated as therapeutic target to promote functional recovery in CNS injuries. Still, the finding that Nogo-A presents a fairly ubiquitous expression in many types of neurons in different brain regions, in the eye and even in the inner ear suggests for further functions besides the neurite growth repression. Indeed, a growing number of studies identified a variety of functions including regulation of neuronal stem cells, modulation of microglial activity, inhibition of angiogenesis and interference with memory formation. Aim of the present commentary is to draw attention on these less well-known and sometimes controversial roles of Nogo-A. Furthermore, we are addressing the role of Nogo-A in neuropathological conditions such as ischemic stroke, schizophrenia and neurodegenerative diseases.

A world soils agenda: Discussing international actions for the sustainable use of soils

Promoting sustainable forms of natural resource management is a challenge land users are unable to tackle solely on their own initiative. Soil and land degradation remains an unresolved problem of global environmental change. There is a need for concerted international action that directly addresses this issue at the global level. A discussion of action to promote the sustainable use of soils and land took place in a working group established by the International Union of Soil Sciences (IUSS) in 1998. The present publication reports on the results of this discussion and proposes that the international community establish a ‘world soils agenda’ that will enable the scientific community, international institutions and their national partners to work together towards the common goal of safeguarding soils and land as resources central to our own survival as well as the Earth’s biological wealth.