Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

Der rettende Begleiter. Der Erzengel Michael ist mehr als nur der Engel, der mit dem Teufel kämpft

Ein Artikel über die Figur des Erzengels Michael und das theologische Engelsverständnis in einer kirchlichen Zeitschrift für ein allgemeines Publikum.

Wissenschaft und Glauben bei Michael Polanyi

For Michael Polanyi, religion and science fight abreast to protect the occidental culture from totalitarian threat. Both are belief-based endeavors, Polanyi is convinced. While this is not surprising at all regarding religion, it is surely a provocation regarding science. The article tries to explore this original thought of Polanyi and to examine how it is rooted in his personal convictions and beliefs. Special emphasis is given to Polanyi’s critique of contemporary biology, as expressed in his article on “Science and Religion”, in some ways a response to Paul Tillich’s theology. Contemporary biology’s findings undermine exactly what Polanyi is fighting for, hence he is convinced that its findings are somewhat flawed. This should however not lead to the false conclusion that Polanyi had anything to do with creationism or would have favored Intelligent Design in our days.