Ändere dich, um dir treu zu bleiben (Interview von Martin Spiewak)

Der Beruf verlangt viel, die Kinder verlassen das Haus, die Eltern sterben. Die Psychologin Pasqualina Perrig-Chiello über eine besonders wechselhafte Lebensphase.

Wissenschaftliche und Religiöse Welterfassung. Ein Kommentar zu Martin Bubers Perspektive auf ein spannungsreiches Thema

Befindet sich die Religion auf dem Rückzug gegenüber der vordringenden Wissenschaft? Welche Theorien gibt es zur Verhältnisbestimmung von Wissenschaft und Religion und was ist ihre wirkliche Differenz? Martin Buber geht diesen Fragen in einem bis vor kurzem noch unveröffentlichten Zürcher Referat nach. Der Essay kommentiert die Bemühungen Bubers um eine Klärung dieser Verhältnisbestimmung und stellt sie in den Kontext der heute international geführten Diskussion über Wissenschaft und Religion.

Sideband-Ratio and Harmonic Response of Sub-Millimeter Wave Mixers measured with a Martin Puplett Interferometer

Heterodyne receivers at millimeter and submillimeter wavelength are widely used for radiometric spectral line observations for atmospheric remote sensing or radio astronomy. The quantitative analysis of such observations requires an accurate knowledge of the mixers's sideband ratio. In addition, its potential sensitivity to spurious harmonics needs to be well understood. In this paper, we discuss a measurement technique for these receiver characteristics, which is based on a scanning Martin Puplett Interferometer used in conjunction with a wide band digital autocorrelation spectrometer for the analysis of the intermediate frequency band. We present measurement results of different double sideband and sideband separating mixers, which were developed for the proposed 340GHz multi-beam limb sounder STEAMR.

Survival with Newly Diagnosed Metastatic Prostate Cancer in the "Docetaxel Era": Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019)

BACKGROUND Prostate cancer (PCa) is the second most common disease among men worldwide. It is important to know survival outcomes and prognostic factors for this disease. Recruitment for the largest therapeutic randomised controlled trial in PCa-the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: A Multi-Stage Multi-Arm Randomised Controlled Trial (STAMPEDE)-includes men with newly diagnosed metastatic PCa who are commencing long-term androgen deprivation therapy (ADT); the control arm provides valuable data for a prospective cohort. OBJECTIVE Describe survival outcomes, along with current treatment standards and factors associated with prognosis, to inform future trial design in this patient group. DESIGN, SETTING, AND PARTICIPANTS STAMPEDE trial control arm comprising men newly diagnosed with M1 disease who were recruited between October 2005 and January 2014. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS Overall survival (OS) and failure-free survival (FFS) were reported by primary disease characteristics using Kaplan-Meier methods. Hazard ratios and 95% confidence intervals (CIs) were derived from multivariate Cox models. RESULTS AND LIMITATIONS A cohort of 917 men with newly diagnosed M1 disease was recruited to the control arm in the specified interval. Median follow-up was 20 mo. Median age at randomisation was 66 yr (interquartile range [IQR]: 61-71), and median prostate-specific antigen level was 112 ng/ml (IQR: 34-373). Most men (n=574; 62%) had bone-only metastases, whereas 237 (26%) had both bone and soft tissue metastases; soft tissue metastasis was found mainly in distant lymph nodes. There were 238 deaths, 202 (85%) from PCa. Median FFS was 11 mo; 2-yr FFS was 29% (95% CI, 25-33). Median OS was 42 mo; 2-yr OS was 72% (95% CI, 68-76). Survival time was influenced by performance status, age, Gleason score, and metastases distribution. Median survival after FFS event was 22 mo. Trial eligibility criteria meant men were younger and fitter than general PCa population. CONCLUSIONS Survival remains disappointing in men presenting with M1 disease who are started on only long-term ADT, despite active treatments being available at first failure of ADT. Importantly, men with M1 disease now spend the majority of their remaining life in a state of castration-resistant relapse. PATIENT SUMMARY Results from this control arm cohort found survival is relatively short and highly influenced by patient age, fitness, and where prostate cancer has spread in the body.

Laura Kalauz & Martin Schicks CMMN SNS PRJCT

Aktuelle Inszenierungen denken den ästhetischen Rahmen, in dem sie sich ereignen, oftmals dezidiert mit. Sie machen ihn zum Thema, stellen ihn zur Disposition oder üben praxisimmanent Kritik am Kunstsystem, in dem sie operieren und von dem sie abhängig sind. Exemplarisch für diese Tendenz fokussiert dieser Aufsatz die 2011 im Rahmen von Freischwimmer entstandene Produktion CMMN SNS PRJCT von Laura Kalauz und Martin Schick. Es wird aufgezeigt, wie Kalauz und Schick einerseits mit den Mitteln des Theaters gesellschaftspolitische Themen in spielerischen Interaktionen gemeinsam mit dem Publikum aushandeln und andererseits das Aufführungsdispositiv sowie Rolle von Rezipienten und Produzenten stets aufs Neue zur Disposition stellen.