Internationalität und Interdisziplinarität der Editionswissenschaft, Berlin/Boston 2014 (Beihefte zu editio 38) [Beiträge der Tagung InterNationalität und InterDisziplinarität der Editionswissenschaft, 15. – 18. Februar 2012 in Bern]

Thema des Bandes ist die in der internationalen Praxis der Editionswissenschaft beobachtbare Vielfalt von wissenschaftsgeschichtlichen Traditionen, texttheoretischen Zugängen und editionspragmatischen Verfahren, die häufig aus der jeweils unterschiedlichen Entwicklung einzelner Nationalphilologien und ihrer tragenden Institutionen resultiert. Diese Heterogenität bereichert die länder- und sprachübergreifende editionswissenschaftliche Kommunikation, erschwert sie aber auch. Hinzu tritt die Tatsache, dass die Editionswissenschaft zunehmend in einem interdisziplinären Austausch steht, an dem in jüngerer Zeit auch die Informations- und Naturwissenschaften teilhaben. In einer von beschleunigter Kommunikation und Globalisierung geprägten Wissensgesellschaft berühren und vermischen sich diese verschiedenen Ansätze, dies nicht zuletzt im Kontext medialer Veränderungen. Zugleich erweisen sich nationale und fachspezifische Konventionen auch unter diesen gewandelten Bedingungen als erstaunlich zählebig – sie bestimmen wissenschaftliche Formen der Interaktion und Kooperation mitunter mehr, als dies den beteiligten Partnern bewusst ist. Diese komplexe Situation bildet den Rahmen für die im Band versammelten Beiträge, die sich mit dem ‚Dazwischen‘ (inter), d.h. mit Synergien und Brüchen nationaler und disziplinärer Zugänge in der Editionswissenschaft auseinandersetzen. Sie dokumentieren die Praxis des gegenwärtigen editorischen Alltags und zeigen, wie unterschiedliche textliche und methodische Voraussetzungen das editorische Endprodukt prägen.

Excited state interactions between the chiral Au 38 L 24 cluster and covalently attached porphyrin

A protected S-acetylthio porphyrin was synthesized and attached to the Au38(2-phenylethanethiolate)24 cluster in a ligand exchange reaction. Chiral high performance liquid chromatography of the functionalized cluster yielded enantiomeric pairs of clusters probably differing in the binding site of the porphyrin. As proven by circular dichroism, the chirality was maintained. Exciton coupling between the cluster and the chromophore is observed. Zinc can be incorporated into the porphyrin attached to the cluster, as evidenced by absorption and fluorescence spectroscopy, however, the reaction is slow. Quenching of the chromophore fluorescence is observed, which can be explained by energy transfer from the porphyrin to the cluster. Transient absorption spectra of Au38(2-phenylethanethiolate)24 and the functionalized cluster probe the bleach of the gold cluster due to ground state absorption and the characteristic excited state absorption signals. Zinc incorporation does not have a pronounced effect on the photophysical behaviour. Decay times are typical for the molecular behaviour of small monolayer protected gold clusters.

37,X/38,XY Mosaicism in a Cryptorchid Bengal Cat with Müllerian Duct Remnants

A 23-month-old tomcat was referred to our clinic because of male behavioral problems, cryptorchidism, and an undefined intra-abdominal organ resembling a uterus. Ultrasonography and computed tomography showed 2 fluid-filled tubular structures dorsolaterally to the bladder and connected to the pelvic urethra. The cat was castrated, and the tubular structures were surgically removed. Histology identified them as Müllerian duct remnants. The testes were hypoplastic, the epididymes and deferent ducts were normal. Cytogenetic analyses revealed the presence of a mosaic 37,X/38,XY karyotype which explains the clinical findings.

Final Results of a Prospective Evaluation of the Predictive Value of Interim Positron Emission Tomography in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP-14 (SAKK 38/07)

PURPOSE Our main objective was to prospectively determine the prognostic value of [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) after two cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone given every 14 days (R-CHOP-14) under standardized treatment and PET evaluation criteria. PATIENTS AND METHODS Patients with any stage of diffuse large B-cell lymphoma were treated with six cycles of R-CHOP-14 followed by two cycles of rituximab. PET/CT examinations were performed at baseline, after two cycles (and after four cycles if the patient was PET-positive after two cycles), and at the end of treatment. PET/CT examinations were evaluated locally and by central review. The primary end point was event-free survival at 2 years (2-year EFS). RESULTS Median age of the 138 evaluable patients was 58.5 years with a WHO performance status of 0, 1, or 2 in 56%, 36%, or 8% of the patients, respectively. By local assessment, 83 PET/CT scans (60%) were reported as positive and 55 (40%) as negative after two cycles of R-CHOP-14. Two-year EFS was significantly shorter for PET-positive compared with PET-negative patients (48% v 74%; P = .004). Overall survival at 2 years was not significantly different, with 88% for PET-positive versus 91% for PET-negative patients (P = .46). By using central review and the Deauville criteria, 2-year EFS was 41% versus 76% (P < .001) for patients who had interim PET/CT scans after two cycles of R-CHOP-14 and 24% versus 72% (P < .001) for patients who had PET/CT scans at the end of treatment. CONCLUSION Our results confirmed that an interim PET/CT scan has limited prognostic value in patients with diffuse large B-cell lymphoma homogeneously treated with six cycles of R-CHOP-14 in a large prospective trial. At this point, interim PET/CT scanning is not ready for clinical use to guide treatment decisions in individual patients.