Mirabilia Urbis Romae. Die Wunderwerke der Stadt Rom

Dieser Text ist gewissermaßen die »Mutter« aller Reiseführer über die ewige Stadt. Er liegt zahlreichen lateinischen und muttersprachlichen Varianten und Redaktionen zugrunde. Zugleich ist er ein wichtiges Zeugnis für die Wiedergeburt der Stadt und ihres Selbstbewusstseins im 12. Jahrhundert. Von diesem Text, der in lateinischer Sprache schwer zugänglich ist, gibt es bislang keine deutsche Übersetzung. In dieser hier erstmals vorgelegten lateinisch-deutschen Ausgabe sind zahlreiche Anmerkungen enthalten. Karten und Bilder der beschriebenen »Wunderwerke« sowie eine bibliophile Ausstattung machen den Band zum Pflichttitel für jeden Romkenner und Romliebhaber. Eine knappe Einleitung zur Stadtgeschichte, zum Pilgerwesen sowie zur Geschichte dieses Führers komplettiert diese Ausgabe.

Ancient History as a Means of Transforming Colonial India in the Late-Eighteenth and Early-Nineteenth Centuries

This article focuses on the studies and discourses of mostly British scholars of the early colonial period belonging to two schools of thought. It shows how the studies of both schools – European orientalism and utilitarianism – were intricately connected to the political development of the emerging British paramountcy over the South Asian sub-continent, as both were looking for means of establishing and/or strengthening colonial rule. Nevertheless, the debate was not just a continuation of discussions in Europe. Whereas the ideas of the European Enlightenment had some influence, the transformation of the Mughal Empire and especially the idea of a decline of Muslim rule offered ample opportunities for understanding the early history of India either as some sort of “Golden Age,” as the orientalists and their indigenous supporters did, or as something static and degenerate, as the utilitarians did, and from which the population of sub-continent had to be saved by colonial rule and colonial values. Fearing the spread of the ideas of the French Revolution, the first group of British scholars sought to persuade the native elites of South Asia to take the lessons of their past for the future development of their homeland. Just as the classicists back in Europe, these scholars were convinced that large-scale explanations of the past could also teach political and moral lessons for the present although it was important to deal with the distant past in an empirical manner. The utilitarians on the other hand believed that India had to be saved from its own depravity through the English language and Western values, which amounted to nothing less than the modern transformation of the true Classical Age.

Comparison against 186 canid whole genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor.

Canine transmissible venereal tumor (CTVT) is a parasitic cancer clone that has propagated for thousands of years via sexual transfer of malignant cells. Little is understood about the mechanisms that converted an ancient tumor into the world's oldest known continuously propagating somatic cell lineage. We created the largest existing catalog of canine genome-wide variation and compared it against two CTVT genome sequences, thereby separating alleles derived from the founder's genome from somatic drivers of clonal transmissibility. We show that CTVT has undergone continuous adaptation to its transmissible allograft niche, with overlapping mutations at every step of immunosurveillance, particularly self-antigen presentation and apoptosis. We also identified chronologically early somatic mutations in oncogenesis- and immune-related genes that may represent key initiators of clonal transmissibility. Thus, we provide the first insights into the specific genomic aberrations that underlie CTVT's dogged perseverance in canids around the world.

Can ancient colour polymorphisms explain why some cichlid lineages speciate rapidly under disruptive sexual selection?

It is not sufficiently understood why some lineages of cichlid fishes have proliferated in the Great Lakes of East Africa much more than anywhere else in the world, and much faster than other cichlid lineages or any other group of freshwater fish. Recent field and experimental work on Lake Victoria haplochromines suggests that mate choice-mediated disruptive sexual selection on coloration, that can cause speciation even in the absence of geographical isolation, may explain it. We summarize the evidence and propose a hypothesis for the genetics of coloration that may help understand the phenomenon. By detl ning colour patterns by hue and arrangement of hues on the body, we could assign almost all observed phenotypes of Lake Victoria cichlids to one of three female («plain», «orange blotched», «black and white») and three male («blue», «red-ventrum», «reddorsum») colour patterns. These patterns diagnose species but frequently eo-occur also as morphs within the same population, where they are associated with variation in mate preferences, and appear to be transient stages in speciation. Particularly the male patterns occur in almost every genus of the species flock. We propose that the patterns and their association into polymorphisms express an ancestral trait that is retained across speciation. Our model for male colour pattern assumes two structural loci. When both are switched off, the body is blue. When switched on by a cascade of polymorphic regulatory genes, one expresses a yellow to red ventrum, the other one a yellow to red dorsum. The expression of colour variation initiates speciation. The blue daughter species will inherit the variation at the regulatory genes that can, without new mutational events, purely by recombination, again expose the colour polymorphism, starting the process anew. Very similar colour patterns also dominate among the Mbuna of Lake Malawi. In contrast, similar colour polymorphisms do not exist in the lineages that have not proliferated in the Great Lakes. The colour pattern polymorphism may be an ancient trait in the lineage (or lineages) that gave rise to the two large haplochromine radiations. We propose two tests of our hypothesis.

Gottes Werk und Adams Beitrag; Formen der Interaktion zwischen Mensch und Gott im Mittelalter

Der Band eröffnet die neue Reihe des Mediävistenverbandes, in der interdisziplinäre Studien aus dem Bereich der Mittelalterforschung veröffentlicht werden. Er dokumentiert ausgewählte Beiträge des 14. Symposiums des Verbandes, das vom 27. bis 31. März 2011 in Jena stattfand. Im Zentrum stehen die mehr oder weniger expliziten Verhältnisbestimmungen des Menschen zu Gott, von denen die monotheistische mittelalterliche Welt in all ihren Bereichen geprägt ist, im Christentum ebenso wie in Islam und Judentum. Dabei geht es um die Wechselbeziehungen zwischen Gott und Mensch, Gottesbild und Menschenbild, Schöpfer und Kreatur sowie göttlicher und menschlicher Schöpfung beziehungsweise Schöpferkraft. Beiträge aus Literatur-, Musik- und Kunstwissenschaft reflektieren unterschiedliche Formen der Kommunikation zwischen Mensch und Gott, historische Hinführungen zur Geschichte von Konzepten und Vorstellungen sind ebenso vertreten wie klassische theologische oder philosophische Studien. So erscheinen die Formen und Inhalte der Interaktion zwischen Gott und Mensch im Mittealter in all ihrer Fülle.