Isoxazolidines and oxazines: preliminary studies for the synthesis of N,O-heterocyclic systems via an organocatalyzed 1,3-Dipolar Cycloaddiction and a tandem reaction mediated by TEMPO salts

This thesis is the result of the study of two reactions leading to the formation of important heterocyclic compounds of potential pharmaceutical interest. The first study concerns the reaction of (1,3)-dipolar cycloaddition between nitrones and activated olefins by hydrogen bond catalysis of thioureas derivatives leading to the formation of a five-membered cyclic adducts, an interesting and strategic synthetic intermediate, for the synthesis of benzoazepine. The second project wants to explore the direct oxidative C(sp3)-H α-alkylation of simple amides with subsequent addition of an olefin and cyclization in order to obtain the corresponding oxazine. Both reactions are still under development.

Synthesis and characterisation of hydrotalcite-like compounds for transesterification reaction

A series of templated [Mg(1-x)Alx(OH)2]x+(CO3)x/n2- with different structural properties have been synthesised using an alkali-free coprecipitation route. The macroporous materials were been obtained using two different kind of templating agents, polymeric materials, in order to cover a bigger size range (750-70 nm). All the materials have been characterized by different techniques: porosimetry, SEM-EDX, TEM-EDX, MP-AES, XRD, CO2 titration before and after the calcinations process. All the materials have been tested for transesterification reaction of C4-C8 triglycerides with methanol for biodiesel production.